Aliccia Bollig-Fischer

Aliccia Bollig-Fischer, PhD
Assistant Professor Department of Oncology
608 HWCRC
4100 John R.
Detroit, MI 48201
313-576-8163
bollig@karmanos.org

Mentoring: Emily Girsch (Year 4), Morenci Manning (Year 3)

Research Interests:

  • Cancer
  • Oncogenes
  • Functional Genomics
  • Systems & Computational Biology
  • Molecular Biomarkers & Targeted Therapeutics

Research Description:

Research in Dr. Bollig-Fischer's laboratory advances cutting-edge genomic methodologies, molecular biology approaches, and innovative bioinformatics. The goal is to tackle clinically relevant cancer research challenges with a strong focus on disparities in outcomes for subsets of patients and related mechanistic understanding of how mutation-activated oncogenes are influenced by other biological factors in their role to drive cancer. In a nutshell, Dr. Bollig-Fischer's research goal is realize the full potential of precision medicine.

Selected Publications:

Teslow EA, Bao B, Dyson G, Legendre C, Mitrea C, Sakr W, Carpten JD, Powell I, Bollig-Fischer A. Exogenous IL-6 induces mRNA splice variant MBD2_v2 to promote stemness in TP53 wild-type, African American PCa cells. Molecular oncology. 2018;
12:1138-52. 

Mitrea C, Wijesinghe P, Dyson G, Kruger A, Ruden DM, Draghici S, Bollig-Fischer A. Integrating 5hmC and gene expression data to infer regulatory mechanisms. Bioinformatics (Oxford, England). 2018;34:1441-7.

Bao B, Mitrea C, Wijesinghe P, Marchetti L, Girsch E, Farr RL, Boerner JL, Mohammad R, Dyson G, Terlecky SR, Bollig-Fischer A. Treating triple negative breast cancer cells with erlotinib plus a select antioxidant overcomes drug resistance by targeting cancer cell heterogeneity. Scientific reports. 2017;7:44125.

Bollig-Fischer A. How the future of clinical cancer diagnostics can contribute to overcoming race-associated cancer disparities. Expert Review of Molecular Diagnostics. 2016;16:1233-5.

Wijesinghe P, Bollig-Fischer A. Lung Cancer Genomics in the Era of Accelerated Targeted Drug Development.  Adv Exp Med Biol. 2016;890:1-23.

Education and Training:
PhD (2003) Michigan State University, East Lansing, MI

Cancer Biology Courses Taught:
CB7240 Principles of Cancer Therapy
CB7300 Functional Genomics and Bioinformatics
CB7990 Research Technologies in Cancer Research