School of Medicine

Wayne State University School of Medicine

Aliccia Bollig-Fischer

Aliccia Bollig-Fischer, PhD
Assistant Professor Department of Oncology
608 HWCRC
4100 John R.
Detroit, MI 48201
313-576-8163
bollig@karmanos.org

Mentoring: Emily Girsch (Year 2)

Research Interests:

  • Cancer
  • Oncogenes
  • Functional Genomics
  • Systems & Computational Biology
  • Molecular Biomarkers & Targeted Therapeutics

Research Description:

Research in Dr. Bollig-Fischer’s laboratory advances cutting-edge genomic methodologies, molecular biology approaches, and innovative bioinformatics. The goal is to tackle clinically relevant cancer research challenges with a strong focus on disparities in outcomes for subsets of patients and related mechanistic understanding of how mutation-activated oncogenes are influenced by other biological factors in their role to drive cancer. In a nutshell, Dr. Bollig-Fischer’s research goal is realize the full potential of precision medicine.

Selected Publications:

Bao B, Mitrea C, Wijesinghe P, Marchetti L, Girsch E, Farr RL, Boerner JL, Mohammad R, Dyson G, Terlecky SR, Bollig-Fischer A. Treating triple negative breast cancer cells with erlotinib plus a select antioxidant overcomes drug resistance by targeting cancer cell heterogeneity. Scientific Reports in press 2017.

Bollig-Fischer A. How the future of clinical cancer diagnostics can contribute to overcoming race-associated cancer disparities. Expert Rev Mol Diagn., 2016;16:1233-5.

Bollig-Fischer A, Michelhaugh SK, Wijesinghe P, Dyson G, Kruger A, Palanisamy N, Choi L, Alosh B, Ali-Fehmi R, Mittal S. Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics.  Oncotarget, 2015;6:14614-24.  

Bollig-Fischer A, Chen W, Gadgeel S, Wenzlaff AS, Cote ML, Schwartz AG, Bepler G. Racial diversity of actionable mutations in non-small cell lung cancer. Journal of Thoracic Oncology, 2015;10:250-5.  

Wijesinghe P, Bepler G, Bollig-Fischer A. Brief Report: A mass spectrometry assay to simultaneously analyze ROS1 and RET fusion gene expression in non-small cell lung cancer. Journal of Thoracic Oncology, 2015;10:381-6.  

Bollig-Fischer A, Marchetti L, Mitrea C, Wu J, Kruger A, Manca V, Draghici S. Modeling time-dependent transcription effects of HER2 oncogene and discovery of a role for E2F2 in breast cancer cell-matrix adhesion. Bioinformatics, 2014;30:3036-43.

Powell IJ and Bollig-Fischer A. Minireview: the molecular and genomic basis for prostate cancer health disparities. Mol. Endocrinol. 2013;27:879-91.

Powell IJ, Dyson G, Land S, Ruterbusch J, Bock CH, Lenk S, Herawi M, Everson R, Giroux CN, Schwartz AG, Bollig-Fischer A. Genes associated with prostate cancer are differentially expressed in African American and European American men. Cancer Epidemiology Biomarkers & Prevention 2013;22:891-7.

Education and Training:
PhD (2003) Michigan State University, East Lansing, MI

Cancer Biology Courses Taught:
CB7240 Principles of Cancer Therapy
CB7300 Functional Genomics and Bioinformatics
CB7990 Research Technologies in Cancer Research