Aliccia Bollig-Fischer, PhD
Assistant Professor Department of Oncology
4100 John R.
Detroit, MI 48201
Mentoring: Emily Girsch (Year 2)
- Functional Genomics
- Systems & Computational Biology
- Molecular Biomarkers & Targeted Therapeutics
Research in Dr. Bollig-Fischer’s laboratory advances cutting-edge genomic methodologies, molecular biology approaches, and innovative bioinformatics. The goal is to tackle clinically relevant cancer research challenges with a strong focus on disparities in outcomes for subsets of patients and related mechanistic understanding of how mutation-activated oncogenes are influenced by other biological factors in their role to drive cancer. In a nutshell, Dr. Bollig-Fischer’s research goal is realize the full potential of precision medicine.
Bao B, Mitrea C, Wijesinghe P, Marchetti L, Girsch E, Farr RL, Boerner JL, Mohammad R, Dyson G, Terlecky SR, Bollig-Fischer A. Treating triple negative breast cancer cells with erlotinib plus a select antioxidant overcomes drug resistance by targeting cancer cell heterogeneity. Scientific Reports in press 2017.
Bollig-Fischer A. How the future of clinical cancer diagnostics can contribute to overcoming race-associated cancer disparities. Expert Rev Mol Diagn., 2016;16:1233-5.
Bollig-Fischer A, Michelhaugh SK, Wijesinghe P, Dyson G, Kruger A, Palanisamy N, Choi L, Alosh B, Ali-Fehmi R, Mittal S. Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics. Oncotarget, 2015;6:14614-24.
Bollig-Fischer A, Chen W, Gadgeel S, Wenzlaff AS, Cote ML, Schwartz AG, Bepler G. Racial diversity of actionable mutations in non-small cell lung cancer. Journal of Thoracic Oncology, 2015;10:250-5.
Wijesinghe P, Bepler G, Bollig-Fischer A. Brief Report: A mass spectrometry assay to simultaneously analyze ROS1 and RET fusion gene expression in non-small cell lung cancer. Journal of Thoracic Oncology, 2015;10:381-6.
Bollig-Fischer A, Marchetti L, Mitrea C, Wu J, Kruger A, Manca V, Draghici S. Modeling time-dependent transcription effects of HER2 oncogene and discovery of a role for E2F2 in breast cancer cell-matrix adhesion. Bioinformatics, 2014;30:3036-43.
Powell IJ and Bollig-Fischer A. Minireview: the molecular and genomic basis for prostate cancer health disparities. Mol. Endocrinol. 2013;27:879-91.
Powell IJ, Dyson G, Land S, Ruterbusch J, Bock CH, Lenk S, Herawi M, Everson R, Giroux CN, Schwartz AG, Bollig-Fischer A. Genes associated with prostate cancer are differentially expressed in African American and European American men. Cancer Epidemiology Biomarkers & Prevention 2013;22:891-7.
Education and Training:
PhD (2003) Michigan State University, East Lansing, MI
Cancer Biology Courses Taught:
CB7240 Principles of Cancer Therapy
CB7300 Functional Genomics and Bioinformatics
CB7990 Research Technologies in Cancer Research