Sreenivasa R. Chinni
Sreenivasa R. Chinni, Ph.D.
9200 Scott Hall
540 E. Canfield
Detroit, MI 48201
- Characterizing cellular and molecular pathological events contributing to prostate cancer progression.
- Chemokine and chemokine receptor axis signaling in lipid raft membrane microdomains of prostate cancer cells.
- Identifying ERG gene transcription targets in prostate cancer cells.
The research focus of my laboratory is to understand the molecular mechanism of prostate cancer metastasis. Currently, we are studying the role of chemokines and chemokine receptors in tumor cell invasion and metastasis using in vitro and in vivo preclinical models of metastasis. Chemokine pathways have been shown to play a key role in primary tumor progression and site specific metastasis. We recently identified that chemokine receptor CXCR4 highly localizes to lipid rich membrane microdomains, activate members of growth factor family receptors and down stream signaling pathways. In tumor cells this transactivation pathway further contributes to intraosseous tumor growth of prostate cancer cells in addition to bone metastasis. Our current studies are directed towards characterizing the molecular intermediates regulating the CXCR4 transactivation of growth factor family receptors in prostate cancer cells. Other project in the lab is to define molecular targets of recently identified recurrent chromosomal alterations in prostate cancer patients. We have identified that androgen activation of common chromosomal translocations, TMPRSS2-ERG induce CXCR4 transcription, and thereby contributing to enhanced invasion and metastasis of prostate cancer cells. We are currently characterizing the functional significance of chromosomal translocations and chemokine receptor expression in prostate cancer metastasis.
Conley-LaComb MK, Semaan L, Singareddy R, Li Y, Heath EI, Kim S, Cher ML, Chinni SR. Pharmacological targeting of CXCL12/CXCR4 signaling in prostate cancer bone metastasis. Mol Cancer. 2016;15:68.
Powell K, Semaan L, Conley-LaComb MK, Asangani I, Wu YM, Ginsburg KB, Williams J, Squire JA, Maddipati KR, Cher ML, Chinni SR. ERG/AKR1C3/AR Constitutes a Feed-Forward Loop for AR Signaling in Prostate Cancer Cells. Clin Cancer Res. 2015;21:2569-79.
Sakao K, Vyas AR, Chinni SR, Amjad AI, Parikh R, Singh SV. CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells. Cancer Prev Res (Phila). 2015;8:365-74.
Education and Training
PhD (1998): University of Louisville, Louisville, Kentucky
Postdoctoral Fellowship (1998-2002): Wayne State University, Detroit, Michigan
Cancer Biology Courses Taught:
CB7210 Fundamentals of Cancer Biology
CB7460 Mechanism of Neoplasia: Alterations to Cellular Signaling