Michele L. Cote

 

 

 

 


 
 

Michele L. Cote, Ph.D.
Associate Professor

Associate Center Director for Education, Karmanos Cancer Institute
Co-Leader for Career Development, CURES, Wayne State University
4100 John R.
Mail Code: MM04EP
Mid-Med Lofts
Detroit, MI 48201
313-578-4204
313-578-4306                                                                                     
cotem@karmanos.org

Mentoring: Andreana Holowatyj  ( Graduated 1/13/2017 ), Asra Shaik  ( Graduated 06/22/2018)

Research Interests:

Cancer health disparities
Molecular epidemiology of lung, breast and female cancers

Research Description:

The focus of Dr. Cote's research is the intersection of molecular epidemiology and health disparities.  Specifically, she is interested in examining genetic and molecular factors in lung and female cancers that impact disease occurrence or prognosis in underserved populations.  Highlights of her previous work include the first report in African Americans of increased risk of lung cancer associated with familial aggregation of lung cancer, and assessment of somatic mutations in endometrial tumors from African American women.

Currently, she is the PI of a NCI R01 (CA200864) examining somatic differences in high grade endometrial cancers between black and white women and a Michigan Department of Health and Human Services funded project to increase tobacco cessation referrals and lung cancer screening in the community setting.  Dr. Cote also works closely with the Metropolitan Detroit Cancer Surveillance System (MDCSS), an original member of the Surveillance, Epidemiology and End Results (SEER) program, and provides her expertise to investigators interested in utilizing this resource.  She is a co-Investigator on a study of ovarian cancer in African American women, an active member of the Epidemiology of Endometrial Cancer Consortium (E2C2), and a Midwest Regional Center Investigator with the Women's Health Initiative.

Recent publications (*indicates trainee):

Shaik AN*, Ruterbusch JJ, Abulfatah E, Shrestha R, Daaboul MHD F, Pardeshi V, Visscher DW, Bandyopadhyay S, Ali-Fehmi R, Cote ML. Breast fibroadenomas are not associated with increased breast cancer risk in an African American contemporary cohort of women with benign breast disease. Breast Cancer Research 2018; July (in press). 

Colacino JA*, Azizi E, Brooks MD, Harouaka R, Fouladdel S, McDermott SP, Lee M, Hill D, Madden J, Boerner J, Cote ML, Sartor MA, Rozek LS, Wicha MS. Heterogeneity of human breast stem and progenitor cells as revealed by transcriptional profiling. Stem Cell Reports. E-published 2018;pii:S2213-6711(18)30107-3.

Holowatyj AN*, Cote ML, Ruterbusch JJ, Ghanem K, Schwartz AG, Vigneau FD, Gorski DH, Purrington KS.  Racial differences in 21-Gene recurrence scores among patients with hormone receptor-positive, node-negative breast cancer. J Clin Oncol. 2018;36:652-8.

Park HK*, Ruterbusch JJ, Cote ML.  Recent trends in ovarian cancer incidence and relative survival in the United States by race/ethnicity and histologic subtypes. Cancer Epidemiol Biomarkers Prev. 2017;26:1511-18.

Gaber C*, Meza R, Ruterbusch JJ, Cote ML. Endometrial cancer trends by race and histology in the USA: Projectivng the number of new cases from 2015 to 2040. J Racial Ethn Health Disparities. 2016 Oct 17. [Epub ahead of Print]

Education and Training:
Ph. D. Epidemiologic Sciences (2004): University of Michigan, Ann Arbor, MI
M.P.H Epidemiology (1996): University of Alabama, Birmingham, AL
B.S. Biology (1994): University of Michigan, Ann Arbor, MI

Cancer Biology Courses Taught:
CB7300 Special Topics F31 Grant Writing Course
CB7300 Special Topics Recent Developments in Breast Cancer Disparities (Course Co-Director)
CB7430 Cancer Epidemiology
CB7700 Recent Developments in Cancer Biology