Michele L. Cote

 

 

 

 


 
 

Michele L. Cote, Ph.D.
Associate Professor

Associate Center Director for Education, Karmanos Cancer Institute
Co-Leader for Career Development, CURES, Wayne State University
4100 John R.
Mail Code: MM04EP
Mid-Med Lofts
Detroit, MI 48201
313-578-4204
313-578-4306                                                                                     
cotem@karmanos.org

Mentoring: Andreana Holowatyj  ( Graduated 1/13/2017 ), Asra Shaik  ( MD/PhD )

Research Interests:

Cancer health disparities
Molecular epidemiology of lung, breast and female cancers

Research Description:

The focus of Dr. Cote's research is the intersection of molecular epidemiology and health disparities.  Specifically, she is interested in examining genetic and molecular factors in lung and female cancers that impact disease occurrence or prognosis in underserved populations.  Highlights of her previous work include the first report in African Americans of increased risk of lung cancer associated with familial aggregation of lung cancer, and assessment of somatic mutations in endometrial tumors from African American women.

Currently, she is the PI of the Komen Graduate Training in Disparities Research grant, which funds 3 PhD students in Cancer Biology, with a focus on breast cancer disparities.  In addition, she is the PI of a NCI R01 (CA200864) examining somatic differences in high grade endometrial cancers between black and white women and a Michigan Department of Health and Human Services funded project to increase tobacco cessation referrals and lung cancer screening in the community setting.  Dr. Cote also works closely with the Metropolitan Detroit Cancer Surveillance System (MDCSS), an original member of the Surveillance, Epidemiology and End Results (SEER) program, and provides her expertise to investigators interested in utilizing this resource.  She is a co-Investigator on a study of ovarian cancer in African American women, an active member of the Epidemiology of Endometrial Cancer Consortium (E2C2) and the International Lung Cancer Consortium (ILCCO), and a Midwest Regional Center Investigator with the Women's Health Initiative.

Selected Publications:

Park HK, Ruterbusch JJ, Cote ML. Recent trends in ovarian cancer incidence and relative survival in the U.S. by race/ethnicity and histologic subtypes. Cancer Epidemiol Biomarkers Prev. 2017 Jul 27. [Epub ahead of print]

Qin B, Moorman PG, Kelemen LE, Alberg AJ, Barnholtz-Sloan JS, Bondy M, Cote ML, Funkhouser E, Peters ES, Schwartz AG, Terry P, Schildkraut JM, Bandera EV. Dietary Quality and Ovarian Cancer Risk in African-American Women.  Am J Epidemiol. 2017:1-9.

Kelemen LE, Abbott S, Qin B, Peres LC, Moorman PG, Wallace K, Bandera EV, Barnholtz-Sloan JS, Bondy M, Cartmell K, Cote ML, Funkhouser E, Paddock LE, Peters ES, Schwartz AG, Terry P, Alberg AJ, Schildkraut JM. Cigarette smoking and the association with serous ovarian cancer in African American women: African American Cancer Epidemiology Study (AACES).  Cancer Causes Control. 2017;28:699-708.

Peres LC, Alberg AJ, Bandera EV, Barnholtz-Sloan J, Bondy M, Cote ML, Funkhouser E, Moorman PG, Peters ES, Schwartz AG, Terry PD, Abbott SE, Camacho F, Wang F, Schildkraut JM. Premenopausal Hysterectomy and Risk of Ovarian Cancer in African-American Women. Am J Epidemiol. 2017:1-8.

Ben Khedher S, Neri M, Papadopoulos A, Christiani DC, Diao N, Harris CC, Olivo-Marston S, Schwartz AG, Cote M, Koushik A, Siemiatycki J, Landi MT, Hung RJ, McLaughlin J, Duell EJ, Andrew AS, Orlow I, Park BJ, Brenner H, Saum KU, Pesatori AC, Stücker I. Menstrual and reproductive factors and lung cancer risk: A pooled analysis from the international lung cancer consortium. Int J Cancer. 2017;141:309-23.

Mahdi Z, Abdulfatah E, Pardeshi V, Hassan O, Schultz D, Morris R, Cote ML, Elshaikh MA, Bandyopadhyay S, Ali-Fehmi R. The Impact of Androgen Receptor Expression on Endometrial Carcinoma Recurrence and Survival.  Int J Gynecol Pathol. 2017 Mar 8. [Epub ahead of print]

Peres LC, Moorman PG, Alberg AJ, Bandera EV, Barnholtz-Sloan J, Bondy M, Cote ML, Funkhouser E, Peters ES, Schwartz AG, Terry PD, Abbott SE, Camacho F, Wang F, Schildkraut JM. Lifetime number of ovulatory cycles and epithelial ovarian cancer risk in African American women. Cancer Causes Control. 2017;28:405-14.

Terry PD, Qin B, Camacho F, Moorman PG, Alberg AJ, Barnholtz-Sloan JS, Bondy M, Cote ML, Funkhouser E, Guertin KA, Peters ES, Schwartz AG, Schildkraut JM, Bandera EV. Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women.  J Nutr. 2017;147:621-7.

Qin B, Moorman PG, Alberg AJ, Barnholtz-Sloan JS, Bondy M, Cote ML, Funkhouser E, Peters ES, Schwartz AG, Terry P, Schildkraut JM, Bandera EV. Dairy, calcium, vitamin D and ovarian cancer risk in African-American women. Br J Cancer. 2016;115:1122-1130.

Gaber C, Meza R, Ruterbusch JJ, Cote ML. Endometrial Cancer Trends by Race and Histology in the USA: Projecting the Number of New Cases from 2015 to 2040. J Racial Ethn Health Disparities. 2016 Oct 17. [Epub ahead of print]

Peres LC, Bandera EV, Qin B, Guertin KA, Shivappa N, Hebert JR, Abbott SE, Alberg AJ, Barnholtz-Sloan J, Bondy M, Cote ML, Funkhouser E, Moorman PG, Peters ES, Schwartz AG, Terry PD, Camacho F, Wang F, Schildkraut JM. Dietary inflammatory index and risk of epithelial ovarian cancer in African American women. Int J Cancer. 2017;140:535-43.

Cote ML, Ruterbusch JJ, Alosh B, Bandyopadhyay S, Kim E, Albashiti B, Radisky DC, Frost MH, Visscher DW, Hartmann LC,  Nassar H, Ali-Femhi R. Benign breast disease and the risk of subsequent breast cancer in African American women.  Cancer Prevention Research 2012;5:1375-80.

Cote ML, Atikukke G, Ruterbusch JJ, Olson SH, Sealy-Jefferson S, Rybicki BA, Hensley Alford S, Elshaikh MA, Gaba AR, Schultz D, Haddad R, Munkarah AR , Ali-Fehmi R.  Racial differences in oncogene mutations detected in early stage, low grade endometrioid endometrial cancers.  Int J Gynecol Cancer 2012;22:1367-72.

 Coté ML, Liu M, Bonassi S, et al. Increased risk of lung cancer among patients with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium. European Journal of Cancer 2012;48:1957-68.

Cote ML, Haddad R, Edwards DJ, Atikukke G, Gadgeel S, Soubani AO, Lonardo F, Bepler G, Schwartz AG, Ethier SP.  Frequency and type of epidermal growth factor receptor mutations in African Americans with non-small cell lung cancer.  J Thorac Oncol, 2011;6:627-30.

Cote ML, Chen W, Smith DW, Behamou S, Bouchardy C, Butkiewicz D, Fong KM, Gene M, Hirvonen A, Kiyohara C, Larsen JE, Lin P, Raaschou-Nielsen O, Povey AC, Reszka E, Risch A, Schneider J, Schwartz AG, Sorensen M, To-Figueras J, Tokudome S, Pu Y, Yang P, Wenzlaff AS, Wikman H, Taioli E.  Meta- and pooled analysis of GSTP1 and lung cancer risk. American Journal of Epidemiology 2009;169:802-814.

Cote ML, Kardia SLR, Wenzlaff AS, Ruckdeschal J, Schwartz AG.  Racial differences in familial aggregation of lung cancer in first degree relatives of early onset lung cancer cases.  Journal of the American Medical Association.  JAMA. 2005;293:3036-3042.

Education and Training:
Ph. D. Epidemiologic Sciences (2004): University of Michigan, Ann Arbor, MI
M.P.H Epidemiology (1996): University of Alabama, Birmingham, AL
B.S. Biology (1994): University of Michigan, Ann Arbor, MI

Cancer Biology Courses Taught:
CB7300 Special Topics F31 Grant Writing Course
CB7300 Special Topics Recent Developments in Breast Cancer Disparities (Course Co-Director)
CB7430 Cancer Epidemiology
CB7700 Recent Developments in Cancer Biology