School of Medicine

Wayne State University School of Medicine

Michele L. Cote






Michele L. Cote, Ph.D.
Associate Professor

Associate Center Director for Education, Karmanos Cancer Institute
Co-Leader for Career Development, CURES, Wayne State University
4100 John R.
Mail Code: MM04EP
Mid-Med Lofts
Detroit, MI 48201

Mentoring: Andreana Holowatyj  (Defended 01/13/2017 ), Asra Shaik  (MD/PhD)

Research Interests:

Cancer health disparities
Molecular epidemiology of lung, breast and female cancers

Research Description:

The focus of Dr. Cote’s research is the intersection of molecular epidemiology and health disparities.  Specifically, she is interested in examining genetic and molecular factors in lung and female cancers that impact disease occurrence or prognosis in underserved populations.  Highlights of her previous work include the first report in African Americans of increased risk of lung cancer associated with familial aggregation of lung cancer, and assessment of somatic mutations in endometrial tumors from African American women.

Currently, she is the PI of the Komen Graduate Training in Disparities Research grant, which funds 3 PhD students in Cancer Biology, with a focus on breast cancer disparities.  In addition, she is the PI of a NCI R01 (CA200864) examining somatic differences in high grade endometrial cancers between black and white women and a Michigan Department of Health and Human Services funded project to increase tobacco cessation referrals and lung cancer screening in the community setting.  Dr. Cote also works closely with the Metropolitan Detroit Cancer Surveillance System (MDCSS), an original member of the Surveillance, Epidemiology and End Results (SEER) program, and provides her expertise to investigators interested in utilizing this resource.  She is a co-Investigator on a study of ovarian cancer in African American women, an active member of the Epidemiology of Endometrial Cancer Consortium (E2C2) and the International Lung Cancer Consortium (ILCCO), and a Midwest Regional Center Investigator with the Women’s Health Initiative.

Selected Publications:

Gaber C, Meza R, Ruterbusch JJ, Cote ML. Endometrial Cancer Trends by Race and Histology in the USA: Projecting the Number of New Cases from 2015 to 2040. J Racial Ethn Health Disparities. 2016 Oct 17.

Holowatyj AN, Ruterbusch JJ, Ratnam M, Gorski DH, Cote ML. HER2 status and disparities in luminal breast cancers. Cancer Med. 2016;5:2109-16.

Meza R, Meernik C, Jeon J, Cote ML. Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010.PLoS One. 2015;10:e0121323.

Cote ML, Alhajj T, Ruterbusch JJ, Bernstein L, Brinton LA, Blot WJ, Chen C, Gass M, Gaussoin S, Henderson B, Lee E, Horn-Ross PL, Kolonel LN, Kaunitz A, Liang X, Nicholson WK, Park AB, Petruzella S, Rebbeck TR, Setiawan VW, Signorello LB, Simon MS, Weiss NS, Wentzensen N, Yang HP, Zeleniuch-Jacquotte A, Olson SH.  Risk factors for endometrial cancer in black and white women: a pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2). Cancer Causes Control. 2015;26:287-96.

Mitro SD, Ali-Fehmi R, Bandyopadhyay S, Alosh B, Albashiti B, Radisky DC, Frost MH, Degnim AC, Ruterbusch JJ, Cote ML. Clinical characteristics of breast cancers in African American women with benign breast disease: A comparison to the Surveillance, Epidemiology and End Results Program.  2014 Sep 8. The Breast Journal.

Ruterbusch JJ, Ali-Fehmi R, Olson SH, Sealy-Jefferson S, Rybicki BA, Hensley-Alford S, Elshaikh MA, Gaba AR, Schultz D, Munkarah AR, Cote ML.  The influence of comorbid conditions on racial disparities in endometrial cancer survival. Am J Obstet Gynecol. 2014 Jun 19 (epub ahead of print)

Cote ML, Ruterbusch JJ, Alosh B, Bandyopadhyay S, Kim E, Albashiti B, Radisky DC, Frost MH, Visscher DW, Hartmann LC,  Nassar H, Ali-Femhi R. Benign breast disease and the risk of subsequent breast cancer in African American women.  Cancer Prevention Research 2012;5:1375-80.

Cote ML, Atikukke G, Ruterbusch JJ, Olson SH, Sealy-Jefferson S, Rybicki BA, Hensley Alford S, Elshaikh MA, Gaba AR, Schultz D, Haddad R, Munkarah AR , Ali-Fehmi R.  Racial differences in oncogene mutations detected in early stage, low grade endometrioid endometrial cancers.  Int J Gynecol Cancer 2012;22:1367-72.

 Coté ML, Liu M, Bonassi S, et al. Increased risk of lung cancer among patients with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium. European Journal of Cancer 2012;48:1957-68.

Cote ML, Haddad R, Edwards DJ, Atikukke G, Gadgeel S, Soubani AO, Lonardo F, Bepler G, Schwartz AG, Ethier SP.  Frequency and type of epidermal growth factor receptor mutations in African Americans with non-small cell lung cancer.  J Thorac Oncol, 2011;6:627-30.

Cote ML, Chen W, Smith DW, Behamou S, Bouchardy C, Butkiewicz D, Fong KM, Gene M, Hirvonen A, Kiyohara C, Larsen JE, Lin P, Raaschou-Nielsen O, Povey AC, Reszka E, Risch A, Schneider J, Schwartz AG, Sorensen M, To-Figueras J, Tokudome S, Pu Y, Yang P, Wenzlaff AS, Wikman H, Taioli E.  Meta- and pooled analysis of GSTP1 and lung cancer risk. American Journal of Epidemiology 2009;169:802-814.

Cote ML, Kardia SLR, Wenzlaff AS, Ruckdeschal J, Schwartz AG.  Racial differences in familial aggregation of lung cancer in first degree relatives of early onset lung cancer cases.  Journal of the American Medical Association.  JAMA. 2005;293:3036-3042.

Education and Training:
Ph. D. Epidemiologic Sciences (2004): University of Michigan, Ann Arbor, MI
M.P.H Epidemiology (1996): University of Alabama, Birmingham, AL
B.S. Biology (1994): University of Michigan, Ann Arbor, MI

Cancer Biology Courses Taught:
CB7300 Special Topics F31 Grant Writing Course
CB7300 Special Topics Recent Developments in Breast Cancer Disparities (Course Co-Director)
CB7430 Cancer Epidemiology
CB7700 Recent Developments in Cancer Biology