Maik Hüttemann, Ph.D.
Wayne State University School of Medicine
Center for Molecular Medicine and Genetics
Department of Biochemistry and Molecular Biology
Karmanos Cancer Institute
3214 Scott Hall
540 East Canfield
Detroit, MI 48201
- Role of mitochondria in cancer and cancer test development based on mitochondrial biomarkers.
- Effect of cell signaling on mitochondrial metabolism, cytochrome c, and cytochrome c oxidase.
- Development of mitochondria-targeted therapies for ischemia/reperfusion injury as seen in stroke and myocardial infarction.
Dr. Hüttemann's team studies mitochondrial function using genetic, biochemical, and functional approaches. The group focuses on two key components of the mitochondrial oxidative phosphorylation machinery, cytochrome c oxidase (COX) and the small electron carrier cytochrome c (Cytc). COX is the terminal enzyme of the mitochondrial respiratory chain, "burns" the oxygen we breathe to water, and pumps protons across the inner mitochondrial membrane generating the mitochondrial membrane potential, which is utilized by ATP synthase to produce energy in the form of ATP. Cytc has two distinct functions: it delivers electrons to COX, but it also participates in programmed cell death (apoptosis). Together the two proteins play a key role in life and death decisions of the cell via energy production under healthy conditions and free radical generation and apoptosis under conditions of cellular stress. The overall goal is to understand the regulation of COX and Cytc in normal and disease conditions including cancer, and to apply this knowledge for diagnosis and treatment.
Li H, Liu J, Wang Y, Fu Z, Huttemann M, Monks TJ, Chen AF, Wang JM. MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in type 2 diabetes. Am J Physiol Endocrinol Metab. 2017 Jul 11:ajpendo.00073.2017. [Epub ahead of print]
Grossman LI, Purandare N, Arshad R, Gladyck S, Somayajulu M, Hüttemann M, Aras S. MNRR1, a Biorganellar Regulator of Mitochondria. Oxid Med Cell Longev. 2017;2017:6739236. Epub 2017 Jun 8. Review.
Sommer N, Huttemann M, Pak O, Scheibe S, Knöpp F, Sinkler C, Malczyk M, Gierhardt M, Esfandiary A, Kraut S, Jonas FT, Veith C, Aras S, Sydykov A, Alebrahimdehkordi N, Giehl K, Hecker M, Brandes RP, Seeger W, Grimminger F, Ghofrani HA, Schermuly RT, Grossman LI, Weissmann N. Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing. Circ Res. 2017 Jun 15. pii: CIRCRESAHA.116.310482. [Epub ahead of print]
Romero R, Erez O, Hüttemann M, Maymon E, Panaitescu B, Conde-Agudelo A, Pacora P, Yoon BH, Grossman LI. Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity. Am J Obstet Gynecol. 2017 Jun 12. pii: S0002-9378(17)30739-1. [Epub ahead of print] Review.
Sinkler CA, Kalpage H, Shay J, Lee I, Malek MH, Grossman LI, Hüttemann M. Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease. Oxid Med Cell Longev. 2017;2017:1534056.
Jung YS, Najy AJ, Huang W, Sethi S, Snyder M, Sakr W, Dyson G, Hüttemann M, Lee I, Ali-Fehmi R, Franceschi S, Struijk L, Kim HE, Kato I, Choi Kim HR. HPV-associated differential regulation of tumor metabolism in oropharyngeal head and neck cancer. Oncotarget. 2017 May 16. [Epub ahead of print]
Tyurina YY, Lou W, Qu F, Tyurin VA, Mohammadyani D, Liu J, Hüttemann M, Frasso MA, Wipf P, Bayir H, Greenberg ML, Kagan VE. Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells. ACS Chem Biol. 2017;12:265-81.
Aras S, Arrabi H, Purandare N, Hüttemann M, Kamholz J, Züchner S, Grossman LI. Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration. Biochim Biophys Acta. 2017;1864:440-8.
Mahapatra G, Varughese A, Ji Q, Lee I, Liu J, Vaishnav A, Sinkler C, Kapralov AA, Moraes CT, Sanderson TH, Stemmler TL, Grossman LI, Kagan VE, Brunzelle JS, Salomon AR, Edwards BF, Hüttemann M. Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: IMPLICATIONS FOR AMP KINASE. J Biol Chem. 2017;292:64-79.
Education and Training:
BS in Chemistry (1992): Philipps-University Marburg, Germany
MS in Chemistry and Biochemistry (1995): Philipps-University Marburg, Germany
PhD in Biochemistry and Molecular Biology (1999): Philipps-University Marburg, Germany
Cancer Biology Courses Taught:
CB7220 Molecular Biology of Cancer Development
CB7700 Recent Developments in Cancer Biology