Jian Wang, M.D., Ph.D.
111 Lande Bldg.
550 E. Canfield Road
Detroit, MI 48201
- Metabolic regulation of cellular growth and differentiation
- Metabolic regulation of epigenetics
- Stem cell and cancer
Nutrient utilization pathways are programmed to satisfy the specific metabolic needs of various cell types including cancer cells. On the other hand, metabolic signals play a critical part in programming gene expression by influencing cellular epigenetic status. Metabolic deregulation is emerging as a hallmark of cancer cells. We are interested in elucidating molecular mechanisms underling the reciprocal relationship between metabolism and gene regulation. Currently we investigate the control mechanisms for cellular acquisition of essential methyl-donors (C1-THF, SAM) for use in biosynthesis and epigenetic modifications. Ongoing projects involve the study of the transcriptional and posttranscriptional regulation of glycine decarboxylase (GLDC) and serine hydroxymethyltransferase (SHMT), the key enzymes mediating C1 acquisition of cells.
Wang, J., Alexander, P. and McKnight, S.L. Metabolic specification of mouse embryonic stem cells. Cold Spring Harb Quant Biol 2011;76:183-93.
Wang, J. and Pantopoulos, K. Regulation of cellular iron metabolism. Biochem J. 2011;434:365-81.
Alexander, P., Wang, J. and McKnight, S.L. Target killing of a mammalian cell based on its specialized metabolic state. Proc. Natl. Acad. Sci. 2011;108:15828-33.
Wang, J. Alexander, P., Wu, L., Hammer, R., Cleaver, O. and McKnight, S.L. Dependence of mouse embryonic stem cell on threonine catabolism. Science 2009;325:435-9.
Education and Training:
MD, 1989, Tongji Medical University
PhD, Experimental Medicine, 2005, McGill University
Postdoctoral, Biochemistry, 2005-2011, the University of Texas Southwestern Medical Center