Benjamin Kidder, Ph.D.
Department of Oncology
4100 John R St
HWCRC Room 624
Detroit, MI 48201
- Stem cell and Cancer Epigenetics
- Transcriptional Networks
- Reprogramming and Transdifferentiation
- Genome Stability
One of the research goals of Dr. Benjamin Kidder’s lab is to understand how stem cells pattern the epigenetic landscape in a way that facilitates unique expression programs throughout development. Humans develop from a single fertilized egg into a complex organism with many cell types, each with its own distinct gene expression and epigenetic profile. These complex cellular states, when perturbed, can lead to disease or cancer. Our lab uses experimental, genomics (next-generation sequencing), and computational biology tools to study the epigenetic regulation of stem cell function, genome stability, and reprogramming/transdifferentiation. We are particularly interested in understanding how histone modifying enzymes contribute to the diverse cellular repertoire that exists in mammals, how epigenetic landscapes are regulated in normal development and disease, and the role for heterochromatin in regulating genome stability.
Kidder BL, Hu G, Cui K, Zhao K. SMYD5 regulates H4K20me3-marked heterochromatin to safeguard ES cell self-renewal and prevent spurious differentiation. EPIGENETICS AND CHROMATIN. 2017. In Press.
Rosati R, Patki M, Chari V1, Dakshnamurthy S, McFall T, Saxton J, Kidder BL, Shaw PE, Ratnam M. The Amino-terminal Domain of the Androgen Receptor Co-opts Extracellular Signal-regulated Kinase (ERK) Docking Sites in ELK1 Protein to Induce Sustained Gene Activation That Supports Prostate Cancer Cell Growth. J BIOL CHEM 2016 Dec 9;291(50):25983-25998. Epub 2016 Oct 28.
Kidder BL, Hu G, Zhao K. KDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation. Genome Biology 2014;15:R32 (Epub).
Kidder BL, Zhao K. Efficient library preparation for next-generation sequencing analysis of genome-wide epigenetic and transcriptional landscapes in embryonic stem cells. Methods in Molecular Biology 2014;1150:3-20.
Kidder BL. Generation of induced pluripotent stem cells using chemical inhibition and three transcription factors. Methods in Molecular Biology 2014;1150:227-36.
Kidder BL. Derivation and manipulation of trophoblast stem cells from mouse blastocysts. Methods in Molecular Biology 2014;1150:201-12.
Kidder BL. In vitro maturation and in vitro fertilization of mouse oocytes and preimplantation embryo culture. Methods in Molecular Biology 2014;1150:191-9.
Kidder BL, Hu G, Yu Z, Liu C, Zhao K. Extended self-renewal and accelerated reprogramming in the absence of Kdm5b. Molecular and Cellular Biology 2013;33:4793-810.
Kidder BL, Palmer S. HDAC1 regulates pluripotency and lineage specific transcriptional networks in embryonic and trophoblast stem cells. Nucleic Acids Research 2012;40:2925-39.
Kidder BL, Hu G, Zhao K. ChIP-Seq: technical considerations for obtaining high quality data. Nature Immunology 2011;12:918-22.
Kidder BL, Palmer S. Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Research 2010;20:458-72.
Kidder BL, Palmer S, Knott JG. SWI/SNF-Brg1 regulates self-renewal and occupies core pluripotency-related genes in embryonic stem cells. Stem Cells 2009; 27:317-28.
Education and Training:
B.A. in Chemistry and Biology (2001): Saint Olaf College, Northfield, MN
Ph.D. in Molecular, Cellular, Developmental Biology and Genetics (2007): University of Minnesota, Minneapolis, MN
Postdoctoral Fellow: EMD/Merck Serono Research Institute, Rockland, MA
Principal Investigator: EMD/Merck Serono Research Institute, Rockland, MA
Research Fellow in Epigenome Biology: National Heart, Lung and Blood Institute (NHLBI, NIH), Bethesda, MD
Cancer Biology Courses Taught:
CB7210 Fundamentals of Cancer Biology
CB7700 Recent Developments in Cancer Biology