Seongho Kim

Seongho Kim, PhD.
Associate Professor
87 East Canfield Street
Detroit, MI 48201

Research Interests:

Pharmacokinetic/Pharmacodynamic (PK/PD) data analysis; High-throughput data analysis; Disease progressive modeling; Metabolomics.

Research Description:
Dr. Kim's research interests lie in the data analysis and the methodology development for biological and clinical cancer data. He has participated in various research projects, including pattern recognitions, decision support systems, comparative genomics, proteomics, metabolomics, pharmacokinetics/pharmacodynamics, biomarker discovery, high-dimensional data analysis, pathway analysis, clinical trial design and cancer screening.

Recent Publications:

Rosati R, Polin LA, Ducker C, Li J, Bao X, Selvakumar D, Kim S, Xhabija B, Larsen M, McFall T, Huang Y, Kidder BL, Fribley A, Saxton J, Kakuta H, Shaw PE, Ratnam M. Strategy for Tumor Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer. Clin Cancer Res. 2018 Sep 5. pii: clincanres.0982.2018. doi: 10.1158/1078-0432.CCR-18-0982. [Epub ahead of print].

Sanai N, Li J, Boerner J, Stark K, Wu J, Kim S, Derogatis A, Mehta S, Dhruv HD, Heilbrun LK, Berens ME, LoRusso PM. Phase 0 Trial of AZD1775 in First-Recurrence Glioblastoma Patients. Clin Cancer Res. 2018;24:3820-28.

Bao X, Wu J, Kim S, LoRusso P, Li J. Pharmacometabolomics Reveals Irinotecan Mechanism of Action in Cancer Patients. J Clin Pharmacol. 2018 Jul 27. doi: 10.1002/jcph.1275. [Epub ahead of print]

Bhutani D, Jaiyeoba C, Kim S, Naylor P, Uberti JP, Ratanatharathorn V, Ayash L, Deol A, Alavi A, Revankar S, Chandrasekar P. Relationship between clostridium difficile infection and gastrointestinal graft versus host disease in recipients of allogeneic stem cell transplantation. Bone Marrow Transplant. 2018 Jul 23. doi: 10.1038/s41409-018-0270-x. [Epub ahead of print].

Prodhan MAI, Yin X, Kim S, McClain C, Zhang X. Surface fitting for calculating the second dimension retention index in comprehensive two-dimensional gas chromatography mass spectrometry. J Chromatogr A. 2018;1539:62-70.

McFall T, McKnight B, Rosati R, Kim S, Huang Y, Viola-Villegas N, Ratnam M. Progesterone receptor A promotes invasiveness and metastasis of luminal breast cancer by suppressing regulation of critical microRNAs by estrogen. J Biol Chem. 2018;293:1163-77.

Li J, Wu J, Bao X, Honea N, Xie Y, Kim S, Sparreboom A, Sanai N. Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood-Brain Barrier in Glioblastoma Patients Using an IVIVE-PBPK Modeling Approach. Clin Cancer Res. 2017;23:7454-66.

Eggly S, Hamel LM, Heath E, Manning MA, Albrecht TL, Barton E, Wojda M, Foster T, Carducci M, Lansey D, Wang T, Abdallah R, Abrahamian N, Kim S, Senft N, Penner LA. Partnering around cancer clinical trials (PACCT): study protocol for a randomized trial of a patient and physician communication intervention to increase minority accrual to prostate cancer clinical trials. BMC Cancer. 2017;17:807.

Modi D, Deol A, Kim S, Ayash L, Alavi A, Ventimiglia M, Bhutani D, Ratanatharathorn V, Uberti JP. Age does not adversely influence outcomes among patients older than 60 years who undergo allogeneic hematopoietic stem cell transplant for AML and myelodysplastic syndrome. Bone Marrow Transplant. 2017;52:1530-36.

Jeyakumar G, Kim S, Bumma N, Landry C, Silski C, Suisham S, Dickow B, Heath E, Fontana J, Vaishampayan U. Neutrophil lymphocyte ratio and duration of prior anti-angiogenic therapy as biomarkers in metastatic RCC receiving immune checkpoint inhibitor therapy. J Immunother Cancer. 2017;5:82.

PubMed Link:

Education and Training:

Post-doctoral Fellow in Biostatistics (2008): Indiana University School of Medicine, Indianapolis, IN
Post-doctoral Fellow in Bioinformatics (2006): Georgia Institute of Technology, Atlanta, GA
PhD in Applied Statistics (2005): KAIST, South Korea

Cancer Biology Courses Taught:
CB7600 Applied Cancer Biostatistics (Course Director)
CB7700 Journal Club
CB7800 Rigor & Reproducibility