Hyeong Reh C. Kim

Hyeong-Reh C. Kim Ph.D.
9271 Scott Hall
540 E. Canfield Ave.
Detroit, MI 48201

Research Description:
The long term objective of Dr. Kim’s research is to unveil the molecular and cellular mechanisms by which proteolytic and growth factor signaling networks contribute to tumor progression.  Dr. Kim’s laboratory has investigated platelet-derived growth factor (PDGF) isoform-specific signal transduction pathways and their roles in prostate and breast cancer progression.   Recently, Dr. Kim’s laboratory showed that tumor-produced PDGF C and D undergo proteolytic activation by the serine proteases uPA and matriptase and mediate stromal reactions, critical for tumor cell invasion and metastasis.  The laboratory of Dr. Kim has also investigated the pleiotropic activity of tissue inhibitor of metalloproteinases (TIMP)-1 during cancer progression.  Dr. Kim’s recent study identified the tetraspanin member CD63 as the first TIMP-1 binding cell surface protein, which mediates the integrin β1 survival pathway as well as phenotypic changes resembling an epithelial mesenchymal transition (EMT).

Selected Publications:

Koh M, Woo Y, Valiathan RR, Jung HY, Park SY, Kim YN, Kim HR, Fridman R, Moon A. Discoidin domain receptor 1 is a novel transcriptional target of ZEB1 in breast epithelial cells undergoing H-Ras-induced epithelial to mesenchymal transition. Int J Cancer. 2014 Aug 23. [Epub ahead of print]

D'Angelo RC, Liu XW, Najy AJ, Jung YS, Won J, Chai KX, Fridman R, Kim HR. TIMP-1 via TWIST1 Induces EMT Phenotypes in Human Breast Epithelial Cells. Mol Cancer Res. 2014;12:1324-33.

Mainetti LE, Zhe X, Diedrich J, Saliganan AD, Cho WJ, Cher ML, Heath E, Fridman R, Kim HR, Bonfil RD. Bone-induced c-kit expression in prostate cancer: A driver of intraosseous tumor growth. Int J Cancer. 2015;136:11-20.

Christensen M, Najy AJ, Snyder M, Movilla LS, Kim HR. A critical role of the PTEN/PDGF signaling network for the regulation of radiosensitivity in adenocarcinoma of the prostate. Int J Radiat Oncol Biol Phys. 2014;88:151-8.

Jung YS, Kato I, Kim HR. A novel function of HPV16-E6/E7 in epithelial-mesenchymal transition. Biochem Biophys Res Commun. 2013;435:339-44.

Education and Training:
PhD (1989): Northwestern University, Evanston, IL
Post-Doc (1990-1991): Northwestern University Cancer Center, Evanston, IL
Post-Doc (1991-1992): Washington University, St. Louis, MO

Cancer Biology Courses Taught:
CB7210 Fundamentals of Cancer Biology