School of Medicine

Wayne State University School of Medicine

Seongho Kim

Seongho Kim, PhD.
Assistant Professor
 87 East Canfield Street
Detroit, MI 48201
313-576-8653
kimse@karmanos.org

Research Interests:

Pharmacokinetic/Pharmacodynamic (PK/PD) data analysis; High-throughput data analysis; Disease progressive modeling; Metabolomics

Research Description:
Dr. Kim's research interests lie in the data analysis and the methodology development for biological and clinical cancer data. He has participated in various research projects, including pattern recognitions, decision support systems, comparative genomics, metabolomics, pharmacokinetics/pharmacodynamics, biomarker discovery, high-dimensional data analysis, pathway analysis, and cancer screening.

Recent Publications:

Kim S, Ouyang M, Jeong J, Shen C, Zhang X. A NEW METHOD OF PEAK DETECTION FOR ANALYSIS OF COMPREHENSIVE TWO-DIMENSIONAL GAS CHROMATOGRAPHY MASS SPECTROMETRY DATA. Ann Appl Stat. 2014;8:1209-1231.

Koo I, Yao S, Zhang X, Kim S. Comparative analysis of false discovery rate methods in constructing metabolic association networks. J Bioinform Comput Biol. 2014;12:1450018.

Li J, Kim S, Sha X, Wiegand R, Wu J, LoRusso P. Complex disease-, gene-, and drug-drug interactions: impacts of renal function, CYP2D6 phenotype, and OCT2 activity on veliparib pharmacokinetics. Clin Cancer Res. 2014;20(:3931-44.

Rosner K, Mehregan DR, Kirou E, Abrams J, Kim S, Campbell M, Frieder J, Lawrence K, Haynes B, Shekhar MP. Melanoma Development and Progression Are Associated with Rad6 Upregulation and β -Catenin Relocation to the Cell Membrane. J Skin Cancer. 2014;2014:439205.

Wei X, Koo I, Kim S, Zhang X. Compound identification in GC-MS by simultaneously evaluating the mass spectrum and retention index. Analyst. 2014;139(:2507-14.

Koo I, Shi X, Kim S, Zhang X. iMatch2: compound identification using retention index for analysis of gas chromatography-mass spectrometry data. J Chromatogr A. 2014;1337:202-10.

Ling J, King KM, Speck BJ, Kim S, Wu D. Preliminary assessment of a school-based healthy lifestyle intervention among rural elementary school children. J Sch Health. 2014;84:247-55.

Wei X, Shi X, Kim S, Patrick JS, Binkley J, Kong M, McClain C, Zhang X. Data dependent peak model based spectrum deconvolution for analysis of high resolution LC-MS data. Anal Chem. 2014;86:2156-65.

Kim S, Li L. Statistical identifiability and convergence evaluation for nonlinear pharmacokinetic models with particle swarm optimization. Comput Methods Programs Biomed. 2014;113:413-32.

Kim S, Zhang X. Comparative analysis of mass spectral similarity measures on peak alignment for comprehensive two-dimensional gas chromatography mass spectrometry. Comput Math Methods Med. 2013;2013:509761

Jang H, Kim S, Wu D. Bayesian lad time estimation for the Johns Hopkins Lung Project data. J Epidemiol Glob Health. 2013;3:157-63

Kim S, Zhang X. Comparative analysis of mass spectral similarity measures on peak alignment for comprehensive two-dimensional gas chromatography mass spectrometry. Computational and Mathematical Methods in Medicine. 2013;1298:132-8.

Jeong J, Zhang X, Shi X, Kim S, Shen C. An efficient post-hoc integration method improving peak alignment of GCxGC/TOF-MS with application to various metabolomics data. BMC Bioinformatics 2013;14:123.

Wei X, Shi X, Koo I, Kim S, Schmidt RH, Arteel GE, Watson WH, McClain C, Zhang X. MetPP: a computational platform for comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry-based metabolomics.  Bioinformatics 2013;29:1786-92.

Koo I, Kim S, Zhang X. Comparative analysis of mass spectral matching-based compound identification in gas chromatography mass spectrometry. Journal of Chromatography A 2013;1298:132-8.

Ling J, King K, Speck B, Kim S, Wu D. Preliminary assessment of a school-based healthy lifestyle program among rural children: Project BALANCE. Journal of School Health.

Wei X, Shi X, Zhong W, Zhao Y, Tang Y, Sun W, Yin X, Bogdanov B, Kim S, McClain C, Zhou Z, Zhang X. Chronic Alcohol Exposure Disturbs Lipid Homeostasis at the Adipose-Liver Axis: Analysis of Triacylglycerols Using High-Resolution Mass Spectrometry in Combination with in vivo Metabolite Deuterium Labeling. PLoS One. 2013;8:e55382.

Kim S, Wu D. Estimation of sensitivity depending on time spent and sojourn time in periodic screening. Statistical Methods in Medical Research. 2012;Nov 4.

Kim S, Li L. A Switching Markov Chain Monte Carlo Method for Statistical Identifiability of Nonlinear Pharmacokinetics Models. Statistica Sinica 2012;22:1199-215.

Kim S, Koo I, Wei X, Zhang X. A method of finding optimal weight factors for compound identification in gas chromatography–mass spectrometry. Bioinformatics 2012;28:1158-63.

Education and Training:
Post-doctoral Fellow in Biostatistics (2008): Indiana University School of Medicine, Indianapolis, INPost-doctoral Fellow in Bioinformatics (2006): Georgia Institute of Technology, Atlanta, GA
PhD in Applied Statistics (2005): KAIST, South Korea

Cancer Biology Courses Taught:
CB7600 Applied Cancer Biostatistics (Course Director)