Adhip P. N. Majumdar, Ph.D., DSc
John D. Dingell VA Medical Center
4646 John R.
Detroit, MI 48201
Age related changes in the gastrointestinal mucosa that lead to malignancy
Study of naturally available dietary agents for cancer treatment
Over the past 30 years, my work has been streamlined to uncover the biochemical and physiological pathways governing the gastrointestinal tract. In that time, I have published well over 175 original scientific articles in peer-review scientific journals, and a multitude of book chapters and review articles. Moreover, as reflected by the literature published from my lab, I am particularly interested in elucidating the pathophysiology of age-related changes in the gastrointestinal mucosa. I am specifically interested in those, which lead to the development of malignancy. To this end, I have studied several naturally available dietary agents including folic acid, resveratrol, and curcumin. We have recently demonstrated that curcumin acts synergistically with resveratrol and chemotherapeutic agents to inhibit colon cancer. In addition, our in vitro studies have demonstrated that the combination of curcumin and the colon cancer therapeutic FOLFOX, inhibits colon cancer growth by effectively eliminating cancer stem cells. Our current strategy is to examine the effectiveness of different natural agents, each alone or in combination, with established chemotherapeutics, in eliminating cancer stem cells thus reducing recurrence without contributing to the toxicity.
Kanwar SS, Yu Y, Nautiyal, Patel BB, Majumdar APN: The Wnt/ β-catenin pathway regulates growth and maintenance of colonospheres. Mol. Cancer. 2010 Aug 6;9:212. PMCID: PMC2924313
Nautiyal J, Yu Y, Aboukameel A, Kanwar S, Das JK, Du J, Patel B, Sarkar F, Rishi AK, Mohammad R, Majumdar APN: ErbB inhibitory protein : a modified ectodomain of EGFR synergizes with dasatinib to inhibit growth of breast cancer cells. Mol. Cancer Ther. 2010 Jun;9(6):1503-14. PMCID: PMC2884079
Kato I, Land S, Majumdar APN, Barnholtz-Sloan J, Severson RK.: Functional polymorphisms to modulate luminal lipid exposure and risk of colorectal cancer. Cancer Epidemiol. 2010 Jun;34(3):291-7. PMCID: PMC:2905870
Yuan L, Yu Y, Sanders MA, Majumdar APN, Basson MD. Schlafen 3 Induction by Cyclic Strain Regulates Intestinal Epithelial Differentiation. Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G994-G1003.
Patel BB, Gupta D, Elliott AA, Sengupta V, Yu Y, Majumdar APN; Curcumin Targets FOLFOX- surviving Colon Cancer Cells via Inhibition of EGFRs and IGF-1R. Anticancer Res. 2010 Feb;30(2):319-25.
Kato I., Nechvatal JM., Dzinic S, Basson MD, Majumdar APN, Ram, JL. Smoking and other personal characteristics as potential predictors for fecal bacteria populations in humans. Med. Sci. Monit. 2010 Jan;16(1):CR1-7.
Oh PS, Patel VB, Sanders MA, Kanwar SS, Yu Y, Nautiyal J, Patel BB, Majumdar APN: Schlafen-3 decreases cancer stem cell marker expression and autocrine/ juxtacrine signaling in FOLFOX-resistant colon cancer cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G347-55. PMCID: PMC3154606
Nautiyal J, Kanwar SS, Yu Y, Majumdar APN: Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells. J Mol Sig. 2011 Jul 20;6:7. PMCID: PMC3162943
Kanwar SS, Yu Y, Nautiyal J, Patel BB, Phadhye S, Sarkar FH, Majumdar APN: Difluorinated- curcumin (CDF): A novel curcumin analog is a potent inhibitor of colon cancer stem-like cells. Pharm Res. 2011 Apr;28(4):827-38.
Nautiyal J, Banerjee S, Kanwar SS, Yu Y, Patel BB, Sarkar FH, Majumdar APN: Curcumin enhances dasatinib induced inhibition of growth and transformation of colon cancer cells. Int J Cancer. 2011 Feb 15;128(4):951-61. PMCID: PMC2939251
Education and Training:
BS in Agricultural Science (1963): University of Kalyani, West Bengal, India
MS in Nutrition (1966): University of London, London, England
PhD in Nutrition (1968): University of London, London, England
DSc in Gastroenterology (1984): University of Aarhus, Aarhus, Denmark
Post-Doc in Molecular Biology (1968-1970): Clinical Research Institute, Montreal, Canada
Post-Doc in Biochemistry (1970-1972): McMaster University, Hamilton, Canada