Adhip P. N. Majumdar, Ph.D., DSc
John D. Dingell VA Medical Center
4646 John R.
Detroit, MI 48201
1. Age related changes in the gastrointestinal mucosa that lead to malignancy
2. Racial Disparity in colorectal cancer
3. Development of therapeutic strategy for recurrent colorectal cancer using naturally available dietary ingredients
Over the past 30 years my work has been streamlined to uncover the biochemical and physiological pathways governing the growth of gastrointestinal tract and have published over 190 original scientific articles in peer-review journals and a multitude of book chapters and review articles. Moreover, as reflected by the literature published from my lab, I am particularly interested in elucidating (a) the patho-physiology of age-related changes in the gastrointestinal mucosa specifically those which lead to the development of malignancy and (b) the underlying molecular/biochemical mechanisms for racial disparity in colorectal cancer. To this end, we have been investigating the role of cancer stem or stem-like cells [that constitute a small sub-population of tumor cells with limitless potential to regenerate] in the development and progression of gastrointestinal malignancies, with particular reference to colorectal cancer, the incidence of which increases sharply with aging and is found to be higher in African Americans than Caucasian Americans. Since cancer stem or stem-like cells are known to be highly resistant to chemotherapy, we have also been pursuing studies to elucidate the molecular mechanisms of therapeutic resistance and develop strategies to eliminate such resistance. Our current strategy is to combine dietary agent(s) with established chemotherapeutics to eliminate cancer stem or stem-like cells thus reducing recurrence without contributing to additional toxicity.
Yu Y, Nangia-Makker P, Farhana L, G Rajendra S, Levi E, Majumdar AP. miR-21 and miR-145 cooperation in regulation of colon cancer stem cells. Mol Cancer. 2015: 4:98.
Sharon C, Baranwal S, Patel NJ, Rodriguez-Agudo D2, Pandak WM, Majumdar AP, Krystal G2, Patel BB. Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo. Oncotarget. 2015,6:15332-47
Vasudevan A, Yu Y, Banerjee S, Woods J, Farhana L, Rajendra SG, Patel A, Dyson G, Levi E, Maddipati KR, Majumdar AP, Nangia-Makker P. Omega-3 Fatty Acid is a potential preventive agent for recurrent colon cancer. Cancer Prev Res. 2014;7:1138-48
Levi E, Sochacki P, Khoury N, Patel BB, Majumdar AP. Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis. World J Gastrointest Pathophysiol. 2014;5:366-72.
Nangia-Makker P, Yu Y, Vasudevan A, Farhana L, Rajendra SG, Levi E, Majumdar AP. Metformin: a potential therapeutic agent for recurrent colon cancer. PLoS One. 2014;9:e84369.
Yang L, Levi E, Zhu S, Du J, Majumdar AP. Cancer stem cells biomarkers in gastric carcinogenesis. J Gastrointest Cancer. 2013;44:428-35.
Roy S, Yu Y, Padhye SB, Sarkar FH, Majumdar AP. Difluorinated-curcumin (CDF) restores PTEN expression in colon cancer cells by down-regulating miR-21. PLoS One. 2013;8:e68543.
Yu Y, Sarkar FH, Majumdar AP. Down-regulation of miR-21 Induces Differentiation of Chemoresistant Colon Cancer Cells and Enhances Susceptibility to Therapeutic Regimens. Transl Oncol. 2013;6:180-6.
Epifano F, Genovese S, Miller R, Majumdar AP. Auraptene and its effects on the re-emergence of colon cancer stem cells. Phytother Res. 2013;27:784-6.
Education and Training
MS in Nutrition (1966): University of London, London, England
PhD in Nutrition (1968): University of London, London, England
DSc in Gastroenterology (1984): University of Aarhus, Aarhus, Denmark
Post-Doc in Molecular Biology (1968-1970): Clinical Research Institute, Montreal, Canada
Post-Doc in Biochemistry (1970-1972): McMaster University, Hamilton, Canada