Adhip P. N. Majumdar, Ph.D., DSc
John D. Dingell VA Medical Center
4646 John R.
Detroit, MI 48201
Age related changes in the gastrointestinal mucosa that lead to malignancy
Study of naturally available dietary agents for cancer treatment
Over the past 30 years, my work has been streamlined to uncover the biochemical and physiological pathways governing the gastrointestinal tract. In that time, I have published well over 175 original scientific articles in peer-review scientific journals, and a multitude of book chapters and review articles. Moreover, as reflected by the literature published from my lab, I am particularly interested in elucidating the pathophysiology of age-related changes in the gastrointestinal mucosa. I am specifically interested in those, which lead to the development of malignancy. To this end, I have studied several naturally available dietary agents including folic acid, resveratrol, and curcumin. We have recently demonstrated that curcumin acts synergistically with resveratrol and chemotherapeutic agents to inhibit colon cancer. In addition, our in vitro studies have demonstrated that the combination of curcumin and the colon cancer therapeutic FOLFOX, inhibits colon cancer growth by effectively eliminating cancer stem cells. Our current strategy is to examine the effectiveness of different natural agents, each alone or in combination, with established chemotherapeutics, in eliminating cancer stem cells thus reducing recurrence without contributing to the toxicity.
Yang L, Levi E, Zhu S, Du J, Majumdar AP. Cancer Stem Cells Biomarkers in Gastric Carcinogenesis. J Gastrointest Cancer. 2013 Aug 16. [Epub ahead of print]
Roy S, Yu Y, Padhye SB, Sarkar FH, Majumdar AP. Difluorinated-curcumin (CDF) restores PTEN expression in colon cancer cells by down-regulating miR-21. PLoS One. 2013;8:e68543.
Yu Y, Sarkar FH, Majumdar AP. Down-regulation of miR-21 Induces Differentiation of Chemoresistant Colon Cancer Cells and Enhances Susceptibility to Therapeutic Regimens. Transl Oncol. 2013;6:180-6.
Epifano F, Genovese S, Miller R, Majumdar AP. Auraptene and its effects on the re-emergence of colon cancer stem cells. Phytother Res. 2013;27:784-6.
Roy S, Majumdar AP. Cancer Stem Cells in Colorectal Cancer: Genetic and Epigenetic Changes. J Stem Cell Res Ther. 2012;Suppl 7(6).
Roy S, Levi E, Majumdar AP, Sarkar FH. Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF. J Hematol Oncol. 2012;5:58.
Roy S, Majumdar AP. Signaling in colon cancer stem cells. J Mol Signal. 2012;7:11.
Leavell BJ, Van Buren E, Antaki F, Axelrod BN, Rambus MA, Majumdar AP. Associations between markers of colorectal cancer stem cells and adenomas among ethnic groups. Dig Dis Sci. 2012;57:2334-9.
Kanwar SS, Poolla A, Majumdar AP. Regulation of colon cancer recurrence and development of therapeutic strategies. World J Gastrointest Pathophysiol. 2012;3:1-9.
Nautiyal J, Du J, Yu Y, Kanwar SS, Levi E, Majumdar AP. EGFR regulation of colon cancer stem-like cells during aging and in response to the colonic carcinogen dimethylhydrazine. Am J Physiol Gastrointest Liver Physiol. 2012;302:G655-63.
Yu Y, Kanwar SS, Patel BB, Oh PS, Nautiyal J, Sarkar FH, Majumdar AP. MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells. Carcinogenesis. 2012;33:68-76.
Levi E, Majumdar AP. Cancer stem cells in ulcerative colitis. Onkologie. 2011;34:660-2.
Nautiyal J, Kanwar SS, Yu Y, Majumdar AP.] Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells. J Mol Signal. 2011;6:7.
Education and Training:
BS in Agricultural Science (1963): University of Kalyani, West Bengal, India
MS in Nutrition (1966): University of London, London, England
PhD in Nutrition (1968): University of London, London, England
DSc in Gastroenterology (1984): University of Aarhus, Aarhus, Denmark
Post-Doc in Molecular Biology (1968-1970): Clinical Research Institute, Montreal, Canada
Post-Doc in Biochemistry (1970-1972): McMaster University, Hamilton, Canada