Kristen S. Purrington

 

 

 

 

 

 

Kristen S. Purrington
Assistant Professor
87 E. Canfield Ave.
Detroit, MI 48201
313-578-4325
purringk@karmanos.org

 

Research Interests:

  • Genetic epidemiology of triple negative breast cancer
  • Biological determinants of mammographic density
  • Racial disparities in triple negative breast cancer rish and survival

Research Description
My research focuses on the genetic epidemiology of triple negative breast cancer with respect to risk, clinical outcomes, and health disparities between African American and European American women. I also have a strong interest in understanding molecular signatures of triple negative breast tumors related to gene expression profiling and underlying genetic variation. Further, my work seeks to understand how these large “omics” data sets may be integrated to better understand triple negative breast cancer etiology, survival, and response to therapy. I am also interested in the combination of genetic factors and traditional epidemiologic risk factors, such as hormonal exposures and mammographic density, and how these may explain risk, biological changes in tumors, and ultimately survival. I am also involved in the Breast Cancer Association Consortium (BCAC) and the Triple Negative Breast Cancer Consortium (TNBCC), two international consortia with primary roles in delineating genetic risk factors for breast cancer risk.

Recent Publications:

Purrington KS, Slettedahl S, Bolla MK, Michailidou K, Czene K, Nevanlinna H, Bojesen SE, Andrulis IL, Cox A, Hall P, Carpenter J, Yannoukakos D, Haiman CA, Fasching PA, Mannermaa A, Winqvist R, Brenner H, Lindblom A, Chenevix-Trench G, Benitez J, Swerdlow A, Kristensen V, Guénel P, Meindl A, Darabi H, Eriksson M, Fagerholm R, Aittomäki K, Blomqvist C, Nordestgaard BG, Nielsen SF, Flyger H, Wang X, Olswold C, Olson JE, Mulligan AM, Knight JA, Tchatchou S, Reed MW, Cross SS, Liu J, Li J, Humphreys K, Clarke C, Scott R; ABCTB Investigators, Fostira F, Fountzilas G, Konstantopoulou I, Henderson BE, Schumacher F, Le Marchand L, Ekici AB, Hartmann A, Beckmann MW, Hartikainen JM, Kosma VM, Kataja V, Jukkola-Vuorinen A, Pylkäs K, Kauppila S, Dieffenbach AK, Stegmaier C, Arndt V, Margolin S; Australian Ovarian Cancer Study Group; kConFab Investigators, Balleine R, Arias Perez JI, Pilar Zamora M, Menéndez P, Ashworth A, Jones M, Orr N, Arveux P, Kerbrat P, Truong T, Bugert P, Toland AE, Ambrosone CB, Labrèche F, Goldberg MS, Dumont M, Ziogas A, Lee E, Dite GS, Apicella C, Southey MC, Long J, Shrubsole M, Deming-Halverson S, Ficarazzi F, Barile M, Peterlongo P, Durda K, Jaworska-Bieniek K, Tollenaar RA, Seynaeve C; The GENICA Network, Brüning T, Ko YD, Van Deurzen CH, Martens JW, Kriege M, Figueroa JD, Chanock SJ, Lissowska J, Tomlinson I, Kerin MJ, Miller N, Schneeweiss A, Tapper WJ, Gerty SM, Durcan L, Mclean C, Milne RL, Baglietto L, Dos Santos Silva I, Fletcher O, Johnson N, Van'T Veer LJ, Cornelissen S, Försti A, Torres D, Rüdiger T, Rudolph A, Flesch-Janys D, Nickels S, Weltens C, Floris G, Moisse M, Dennis J, Wang Q, Dunning AM, Shah M, Brown J, Simard J, Anton-Culver H, Neuhausen SL, Hopper JL, Bogdanova N, Dörk T, Zheng W, Radice P, Jakubowska A, Lubinski J, Devillee P, Brauch H, Hooning M, García-Closas M, Sawyer E, Burwinkel B, Marmee F, Eccles DM, Giles GG, Peto J, Schmidt M, Broeks A, Hamann U, Chang-Claude J, Lambrechts D, Pharoah PD, Easton D, Pankratz VS, Slager S, Vachon CM, Couch FJ. Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade. Hum Mol Genet. 2014 Jun 13. [Epub ahead of print]

Purrington KS, Slager S, Eccles D, Yannoukakos D, Fasching PA, Miron P, Carpenter J, Chang-Claude J, Martin NG, Montgomery GW, Kristensen V, Anton-Culver H, Goodfellow P, Tapper WJ, Rafiq S, Gerty SM, Durcan L, Konstantopoulou I, Fostira F, Vratimos A, Apostolou P, Konstanta I, Kotoula V, Lakis S, Dimopoulos MA, Skarlos D, Pectasides D, Fountzilas G, Beckmann MW, Hein A, Ruebner M, Ekici AB, Hartmann A, Schulz-Wendtland R, Renner SP, Janni W, Rack B, Scholz C, Neugebauer J, Andergassen U, Lux MP, Haeberle L, Clarke C, Pathmanathan N, Rudolph A, Flesch-Janys D, Nickels S, Olson JE, Ingle JN, Olswold C, Slettedahl S, Eckel-Passow JE, Anderson SK, Visscher DW, Cafourek VL, Sicotte H, Prodduturi N, Weiderpass E, Bernstein L, Ziogas A, Ivanovich J, Giles GG, Baglietto L, Southey M, Kosma VM, Fischer HP; GENICA Network, Reed MW, Cross SS, Deming-Halverson S, Shrubsole M, Cai Q, Shu XO, Daly M, Weaver J, Ross E, Klemp J, Sharma P, Torres D, Rüdiger T, Wölfing H, Ulmer HU, Försti A, Khoury T, Kumar S, Pilarski R, Shapiro CL, Greco D, Heikkilä P, Aittomäki K, Blomqvist C, Irwanto A, Liu J, Pankratz VS, Wang X, Severi G, Mannermaa A, Easton D, Hall P, Brauch H, Cox A, Zheng W, Godwin AK, Hamann U, Ambrosone C, Toland AE, Nevanlinna H, Vachon CM, Couch FJ. Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. Carcinogenesis. 2014;35:1012-9

Glatz AC, Purrington KS, Klinger A, King AR, Hellinger J, Zhu X, Gruber SB, Gruber PJ. Cumulative exposure to medical radiation for children requiring surgery for congenital heart disease. J Pediatr. 2014;164:789-794.e10.

Education and Training:
Postdoctoral Research Fellow, (2010-2013) Department of Health Sciences Research, Mayo Clinic - Rochester, MN
Ph.D. Epidemiology, 2010 University of Michigan, Ann Arbor, MI, Rackham Graduate School
M.A. Statistics, 2010 University of Michigan, Ann Arbor, MI, Rackham Graduate School
M.P.H. Epidemiology,2007 University of Michigan, Ann Arbor, MI, School of Public Health
B.S. Cellular and Molecular Biology, 2005 University of Michigan, Ann Arbor, MI, College of Literature, Arts and Sciences

Cancer Biology Courses Taught:
CB7210 Fundamentals of Cancer Biology
CB7300 Special Topics Recent Developments in Breast Cancer Disparities (Course Co-Director)

CB7430 Cancer Epidemiology (Course Co-Director)
CB7700 Recent Developments in Cancer Biology