School of Medicine

Wayne State University School of Medicine

Fazlul H. Sarkar

Fazlul H. Sarkar, Ph.D.
4100 John R. 
Hudson Webber CRC, 740
Detroit, MI 48201
Assistant: Jacqui 313-576-8325 

Research Interests:
• NF-κB
• Natural chemopreventive agents
• Sensitization of cancer cells to therapeutics
• microRNAs (miRNAs)
• cell signaling and cancer stem cells or EMT phenotypic cells

Research Description:
Research in the Sarkar laboratory is focused on understanding the role of a “master” transcription factor, NF-κB and the regulation of its upstream and downstream signaling molecules in solid tumors. Other studies are directed toward elucidating the molecular mechanisms of action of “natural agents” and synthetic small molecules for cancer prevention and therapy. His work has led to the discovery of the role of chemopreventive agents in sensitization of cancer cells (reversal of drug-resistance) to conventional therapeutics (chemo-radio-therapy). Finally studies are focused on cancer stem cells, epithelial mesenchymal transition (EMT), drug resistance and miRNAs.

Selected Publications:

Hillman GG, Singh-Gupta V, Lonardo F, Hoogstra DJ, Abernathy LM, Yunker CK, Rothstein SE, Rakowski J, Sarkar FH, Gadgeel S, Konski AA, Joiner MC. Radioprotection of Lung Tissue by Soy Isoflavones. J Thorac Oncol. 2013 Sep 26.

Dandawate P, Padhye S, Ahmad A, Sarkar FH. Novel strategies targeting cancer stem cells through phytochemicals and their analogs. Drug Deliv Transl Res. 2013;3:165-182.

Ahmed A, Ali S, Sarkar FH. Advances in androgen receptor targeted therapy for prostate cancer. J Cell Physiol. 2013 Aug 22.

Hillman GG, Singh-Gupta V, Hoogstra DJ, Abernathy L, Rakowski J, Yunker CK, Rothstein SE, Sarkar FH, Gadgeel S, Konski AA, Lonardo F, Joiner MC. Differential effect of soy isoflavones in enhancing high intensity radiotherapy and protecting lung tissue in a pre-clinical model of lung carcinoma. Radiother Oncol. 2013 Sep 7.

Azmi AS, Bollig-Fischer A, Bao B, Park BJ, Lee SH, Yong-Song G, Dyson G, Reddy C, Sarkar FH, Mohammad RM.
Systems analysis reveals a transcriptional reversal of the mesenchymal phenotype induced by SNAIL-inhibitor GN-25.
BMC Syst Biol. 2013 ;7:85.

Bao B, Azmi AS, Li Y, Ahmad A, Ali S, Banerjee S, Kong D, Sarkar FH. Targeting CSCs in Tumor Microenvironment: The Potential Role of ROS-Associated miRNAs in Tumor Aggressiveness. Curr Stem Cell Res Ther. 2013 Aug 16.

Li Y, Ahmad A, Kong D, Bao B, Sarkar FH. Targeting MicroRNAs for Personalized Cancer Therapy. Med Princ Pract. 2013;22:415-7.

Roy S, Yu Y, Padhye SB, Sarkar FH, Majumdar AP. Difluorinated-curcumin (CDF) restores PTEN expression in colon cancer cells by down-regulating miR-21. PLoS One. 2013 ;8:e68543.

Sethi S, Ali S, Philip PA, Sarkar FH. Clinical advances in molecular biomarkers for cancer diagnosis and therapy. Int J Mol Sci. 2013;14:14771-84.

Sethi S, Li Y, Sarkar FH. Regulating miRNA by natural agents as a new strategy for cancer treatment. Curr Drug Targets. 2013;14:1167-74.

Ahmad A, Biersack B, Li Y, Bao B, Kong D, Ali S, Banerjee S, Sarkar FH. Perspectives on the Role of Isoflavones in Prostate Cancer. AAPS J. 2013;15:991-1000.

Bao B, Ahmad A, Azmi AS, Ali S, Sarkar FH. Overview of cancer stem cells (CSCs) and mechanisms of their regulation: implications for cancer therapy. Curr Protoc Pharmacol. 2013;14:14.25.

Azmi AS, Bao B, Sarkar FH. Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review.
Cancer Metastasis Rev. 2013 May 25.

Education and Training:
BSc in Physics (1971): Chemistry, and Math: Calcutta University, India (Distinction)
MSc in Biochemistry (1974): Aligarh Muslim University, India (First Class)
PhD in Biochemistry (1978): Banaras Hindu University, India