Ann G. Schwartz
Ann G. Schwartz, Ph.D., M.P.H.
Deputy Center Director
Executive Vice President for Research and Academic Affairs
Professor
Karmanos Cancer Institute
4100 John R.
Detroit, MI 48201
313-578-4201
schwarta@karmanos.org
Research Interests:
- Epidemiologic studies of cancer risk and progression
- Focus on genetic and molecular epidemiology
Dr. Schwartz is the Deputy Director and Executive Vice President for Research and Academic Affairs at the Karmanos Cancer Institute and a Professor in the Department of Oncology at Wayne State University School of Medicine. In 2009, she served as Interim President and CEO of the Karmanos Cancer Institute. Dr. Schwartz has been continuously funded by the National Cancer Institute for 20 years, has over 115 publications, and serves as a reviewer for numerous journals and NIH grants, including a recent term on Subcommittee A, the parent committee for Comprehensive Cancer Center Support Grants. Her lung cancer studies have focused on familial aggregation of lung cancer, producing the first estimates of lung cancer risk to relatives in African Americans, evaluation of candidate genes in smoking and estrogen metabolism pathways, and gene discovery using admixture mapping in African Americans. Most recently she has published in the area of inflammation and lung cancer risk, showing 1) increased risk of lung cancer with a history of chronic obstructive lung diseases collectively, and emphysema and chronic bronchitis separately, 2) decreased risk associated with NSAID use, 3) variation in risk and survival associated with SNPs in inflammatory genes, and 4) decreased survival associated with COX-2 but not with EGFR expression in lung tumors in both white and African Americans. Dr. Schwartz has also conducted gene expression studies in prostate cancer using custom array panels for a study of racial disparities in prostate cancer aggressiveness. She is an active participant in two lung cancer consortiums, the Genetic Epidemiology of Lung Cancer Consortium (GELCC) and the International Lung Cancer Consortium (ILCCO), and a pancreatic cancer gene discovery consortium (PacGene).
Selected Publications:
Amos CI, Pinney SM, Li Y, Kupert E, Lee J, deAntrade MA, Yang P, Schwartz AG, Fain PR, Gasdar A, Minna J, Wiest JS, Zeng D, Rothschild H, Mandal D, You M, Coons T, Gaba C, Bailey-Wilson JE, Anderson MW. A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers. Cancer Res 2010 Mar 15;70(6): 2359-67. PMCID: PMC2855643
Gadgeel SM, Cote ML, Schwartz AG, Matherly LH, Wozniak A, Bepler G. Parameters for individualizing systemic therapy in non-small cell lung cancer. Drug Resist Updat 2010. Dec;13(6):196-204.
Cote ML, Haddad R, Edwards DJ, Atikukke G, Gadgeel S. Soubani AO, Lonardo F, Bepler G, Schwartz AG, Ethier SP. Frequency and type of epidermal growth factor receptor mutations in African Americans with non-small cell lung cancer. J Thorac Onc. 2011 Mar; 6(3):627-30. PMCID: PMC3057407
Schwartz AG, Wenzlaff AS, Bock CH, Ruterbusch JJ, Chen W, Cote ML, Artis A, VanDyke AL, Land S, Harris CC, Pine S, Spitz M, Amos CI, Levin AM, McKeigue P. Admixture Mapping of Lung Cancer in 1,812 African Americans. Carcinogenesis. Mar 2011; 32 (3):312-7. PMCID: PMC3047238
Hinch AG, Tandon A, Patterson N, Song Y, Rohland N, Palmer CD, Chen GK, Wang K, Buxbaum SG, Akylbekova EL, Aldrich MC, Ambrosone CB, Amos C, Bandera EV, Berndt SI, Bernstein L, Blot WJ, Bock CH, Boerwinkle E, Cai Q, Caporaso N, Casey G, Cupples LA, Deming SL, Diver WR, Divers J, Fornage M, Gillanders EM, Glessner J, Harris CC, Hu JJ, Ingles SA, Isaacs W, John EM, Kao WH, Keating B, Kittles RA, Kolonel LN, Larkin E, Le Marchand L, McNeill LH, Millikan RC, Murphy A, Musani S, Neslund-Dudas C, Nyante S, Papanicolaou GJ, Press MF, Psaty BM, Reiner AP, Rich SS, Rodriguez-Gil JL, Rotter JI, Rybicki BA, Schwartz AG, Signorello LB, Spitz M, Strom SS, Thun MJ, Tucker MA, Wang Z, Wiencke JK, Witte JS, Wrensch M, Wu X, Yamamura Y, Zanetti KA, Zheng W, Ziegler RG, Zhu X, Redline S, Hirschhorn JN, Henderson BE, Taylor HA Jr, Price AL, Hakonarson H, Chanock SJ, Haiman CA, Wilson JG, Reich D, Myers SR. The Landscape of Recombination in African Americans. Nature. 2011. Jul 20;476(7359):170-5. PMCID: PMC3154982
Education and Training:
BS in Biology (1978): University of Michigan, Ann Arbor, Michigan
MS in Biology (1979): Wayne State University, Detroit, Michigan
MPH in Environmental Health (1981): University of Michigan School of Public Health, Ann Arbor, Michigan
PhD in Epidemiology (1986): University of Michigan School of Public Health, Ann Arbor, Michigan