Xiaohong (Mary) Zhang

Xiaohong (Mary)  Zhang, Ph.D.
Associate Professor
Department of Oncology
Molecular Therapeutic Program
Karmanos Cancer Institute
Wayne State University School of Medicine
716 HWCRC
4100 John R.
Detroit, MI 48201
313-576-8672
zhangx@karmanos.org

Mentoring: Nicolette Moses ( Year 3 )

Research Interests:

  • Function and regulation of histone deacetylases (HDACs) in lung cancer and chemosensitivity
  • Identification of novel enzymatic activities in HDACs
  • Assessment of HDAC inhibitors in human cancer cell lines and animal models
  • Examination of the post-translational modifications in DNA repair proteins

Research Description:
Dr. Zhang’s lab has a long-standing interest in the role of histone deacetylases (HDACs) in lung cancer and chemoresistance.  Her lab was among the first to reveal that HDAC6 is associated with cisplatin sensitivity in lung and ovarian cancer cell lines. Her team has also identified the extracellular signal-regulated kinase 1/2   (ERK1/2) as a modulator for HDAC6’s enzymatic activity. Most significantly, her group discovered a novel ubiquitin E3 ligase activity within HDAC6 and linked HDAC6 to DNA mismatch repair and DNA damage response. Currently, there are three ongoing projects in her lab: 1) To explore the mechanisms by which HDAC6 regulates lung cancer sensitivity to tyrosine kinase inhibitors (TKIs); 2) To elucidate how ubiquitin-specific peptidase 10 (USP10) governs cisplatin sensitivity via HDAC6; 3) To explore how HDAC6 regulates ERK1 function via deacetylation.  

Recent Publications:

Radhakrishnan  R, Li Y, Xiang S, Yuan F, Yuan Z, Telles E, Fang J, Coppola D, Shibata D, Lane W S, Zhang Y, Zhang X* (co-corresponding author), and Seto E. (2015) Histone Deacetylase 10 Regulates DNA Mismatch Repair and May Involve the Deacetylation of MutS Homolog 2. J. Biol. Chem  2015;290:22795-804. 

Sun Y, Sun J, Lungchukiet P, Quarni W, Yang S, Zhang X, Bai W. (2015) Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation. Sci Rep. 2015;5:11529.

Lungchukiet P, Sun Y, Kasiappan R, Quarni W, Nicosia SV, Zhang X, and Bai W. Suppression of epithelial ovarian cancer invasion into the omentum by 1alpha,25-dihydroxyvitamin D3 and its receptor. J Steroid Biochem Mol Biol 2015;148:138-147.

Nelson N, Xiang S, Zhang X, Gilvary D, Djeu J, Husain K, Malafa M, Vohra N, Pilon-Thomas S, Ghansah T. Murine pancreatic adenocarcinoma reduces Ikaros expression and disrupts T cell homeostasis. PLoS One. 2015;10:e0115546.

Dobrinski, K, Exposito NN, Kruk PA, Wenham R, Hoffman M, Coppola D, Bai W, Zhang X, Siddique N, and Nicosia SV. Procurement and cytological features of human fallopian tube fimbrial cells by ex vivo imprinting and washing. Journal of the American Society of Cytopathology 2014;3:309-318

Kasiappan R, Sun Y, Lungchukiet P, Quarni W, Zhang X, Bai W. (2014) Vitamin D suppresses leptin stimulation of cancer growth through MicroRNA. Cancer Res. 2014;74:6194-204.

Zhang M, Xiang S, Joo H-Y, Wang, L,  Williams, K, Liu W, Hu C, Tong D, Haakenson J, Wang C, Zhang S, Pavlovicz RE, Jones A, Schmidt KH, Tang J, Dong H, Shan B, Fang B, Radhakrishnan R, Glazer PM, Matthias P, Koomen J, Seto E, Bepler G, Nicosia SV, Chen J., Li C, Gu L, Li G-M,  Bai W, Wang H, Zhang X*.  HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSa. Mol. Cell 2014;55:31-46.

Sun Y, Kasiappan R, Tan J, Webb PL, Quarni W, Zhang X, Bai W. A novel function of the Fe65 neuronal adaptor in estrogen receptor action in breast cancer cells J. Biol. Chem 2014;289:12217-31.

Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, Ryan M, Cox AD, Der CJ, Fang B, Koomen J, Haura E, Bepler G, Nicosia SV, Matthias P, Wang C, Bai W, Zhang X*. Extracellular Signal-Regulated Kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at Serine 1035 to stimulate cell migration. J. Biol. Chem  2013;15;288:33156-70.

Wang L, Xiang S, Williams KA, Dong H, Bai W, Nicosia, SV, Khochbin S, Bepler G, Zhang X*. (2012) Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells PLoS ONE 2012;7:e44265.

Education and Training:
Ph.D. (1998)  U.T. M. D. Anderson Cancer Center, Houston, Texas

Cancer Biology Courses Taught:
CB7600 Applied Cancer Biostatistics
CB7700 Recent Developments in Cancer Biology