Larry H. Matherly, Ph.D.
Director, Cancer Biology Graduate Program
Program Leader, Molecular Therapeutics Program
Professor of Oncology and Pharmacology
Principal Investigator, T32 CA009531
Research Interests: Basic biology of membrane transporters; drug discovery; translational studies and chemotherapy response and resistance; biology and therapeutic applications of folates and related analogs.
George S. Brush, Ph.D.
Associate Director and Graduate Officer, Cancer Biology Graduate Program
Associate Professor of Oncology
Research Interests: DNA damage and recombination checkpoints; Regulation of pre-meiotic DNA replication; Transcription mechanisms in early meiosis.
Michele Cote, Ph.D.
Director of Cancer Biology Graduate Admissions
Principle Investigator Susan G. Komen Graduate Training in Disparities Research Grant
Research Interests: Cancer epidemiology, Molecular epidemiology of lung cancer, Disparities in endometrial cancer survival. Disparities in breast and endometrial cancer incidence and survival.
Raymond R. Mattingly, Ph.D.
Research Interests: Pathophysiological roles and pharmacological significance of small GTPases of the Ras superfamily. Development of 3D in vitro models for testing new pharmacological approaches and drug combinations.
Stephan Patrick, Ph.D.
Research Interests: DNA Repair pathways and understanding how they mediate cisplatin efficacy, targeting DNA repair to overcome chemotherapy drug resistance, Understanding the bystander effect following cisplatin treatment, chromatin remodeling and how it influences DNA repair.
Manohar Ratnam, P.D.
Director of Career Development
Research Interests: Detailed studies of new molecular mechanisms that drive the hormone-dependent growth of breast and prostate cancers; establishing new mechanism-based paradigms for treatment. Development of new folate receptor targeted therapies for acute myelogenous leukemia. Developing folate receptor based early detection strategies for ovarian cancer.
Malathy Shekhar, Ph.D.
Professor of Oncology and Pathology
Research Interests: Breast cancer research; Rad6 and postreplication DNA repair pathway: drug sensitivity/resistance mechanisms, gene regulation, and stabilization/activation of Wnt/beta-catenin signaling; stromal-epithelial interactions and its role in hormonal sensitivity/resistance.