Joshua Heyza

Joshua Heyza
Senior Student

Dissertation Mentor: Stephan Patrick, Ph.D.

Research Focus: 
Understanding the role of p53 in mediating sensitivity to platinum-based chemotherapy in NER-deficient tumors. Identifying mechanistic roles of ERCC1 splice variants in modulating cisplatin cytotoxicity. 

Grants, Awards & Scholarships:
2017 Molecular Therapeutics Annual Research Retreat 1st Place - Poster Presentation
2017 - 2018 Ruth L. Kirschenstein Research Training Recipient (T32-CA009531) Reappointment, Wayne State University
2016 - 2017 Ruth L. Kirschenstein Research Training Recipient (T32-CA009531), Wayne State University
18th Annual Midwest DNA Repair Symposium, The Ohio State University - 1st Place Poster Presentation
 6th  Annual Cancer Biology Symposium, Wayne State University School of Medicine - 1st Place Poster Presentation
2014 Cancer Biology Director's Award, Wayne State University School of Medicine


Joshua R. Heyza*, Sanjeevani Arora*, Hao Zhang, Kayla L. Conner, Wen Lei, Ashley M. Floyd, Rahul R. Deshmukh, Jeffrey Sarver, Christopher J. Trabbic, Paul Erhardt, Tak-Hang Chan, Q. Ping Dou and Steve M. Patrick. Targeting the DNA Repair Endonuclease ERCC1-XPF with Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) and Its Prodrug to Enhance Cisplatin Efficacy in Human Cancer Cells. Nutrients 2018;10:1644  *Authors contributed equally

Arora, S.; Heyza, J.R.; Chalfin, E.C.; Ruch, R.J.; Patrick, S.M. Gap Junction Intercellular Communication Positively Regulates Cisplatin Toxicity by Inducing DNA Damage through Bystander Signaling. Cancers 2018;10:368.

Arora, S., Heyza, J., Zhang, H., Kalman-Maltese, V., Tillison, K., Floyd, A., Chalfin, E., Bepler, G., & Patrick, S. (2016). Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells. Oncotarget 2016;7:75104-17.

K. Ji, J. Heyza, D. Cavallo-Medved, B.F. Sloane, Pathomimetic Cancer Avatars for Live-Cell Imaging of Protease Activity, Biochimie 2016;122:68-76.

BS with Honors, Biology, University of Michigan-Flint

Flint, MI