School of Medicine

Wayne State University School of Medicine

Michael Wilson

 

Michael Wilson
Senior Student

Dissertation Mentor: Larry Matherly, PhD

Research Focus:
PCFT Structure

Grants, Awards, Scholarships:
Rumble's Fellowship 2015 - 2016
2015 Molecular Therapeutics Annual Research Symposium Poster Presentation Award 1st Place
2015 Cancer Biology Research Symposium Poster Presentation Award 3rd Place
NRSA T32 Training Grant Fellowship Reappointment 2014-2015
2014 Molecular Therapeutics Annual Research Symposium Poster Presentation Award 1st Place
2014 Cancer Biology Research Symposium Oral Presentation Award 2nd Place
NRSA T32 Training Grant Fellowship 2013-2014 


Publications:
Wilson M.R., Hou Z., Yang S., Polin L., Kushner J., White K., Huang J., Ratnam M., Gangjee A., Matherly L.H. Targeting Non-Squamous Non-Small Cell Lung Cancer Via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates. Mol Pharmacol. 2016. Feb 2. pii: mol.115.102798.

Wang L, Wallace A, Raghavan S, Deis SM, Wilson MR, Yang S, Polin L, White K, Kushner J, Orr S, George C, O'Connor C, Hou Z, Mitchell-Ryan S, Dann CE 3rd, Matherly LH, Gangjee A. 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors. 
J Med Chem. 2015;58:6938-59.

Wilson MR, Kugel S, Huang J, Wilson LJ, Wloszczynski PA, Ye J, Matherly LH, Hou Z. Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6. Biochem J. 2015;469:33-44.

Golani LK, George C, Zhao S, Raghavan S, Orr S, Wallace A, Wilson MR, Hou Z, Matherly LH, Gangjee A. Structure-Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter. J Med Chem. 2014;57:8152-66.

Wilson MR, Hou Z, Matherly LH. Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter. J Biol Chem. 2014;289:25287-95.

Matherly LH, Wilson MR, Hou Z. The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer. Drug Metab Dispos. 2014;42:632-49.

Education:
Grand Valley State University, B.S. Cell & Molecular Biology

Hometown:
Walled Lake, Michigan