Yubin Ge, Ph.D.
Address
421 E. Canfield Street, Suite 3128 Detroit, MI 48201Office address
421 E. Canfield Street, Suite 3128
Detroit, MI 48201
Mentoring
Jenna Thibodeau
Kian Hershberger
Department
OncologyResearch interests
Translational studies of acute myeloid leukemia including myeloid leukemia associate with Down syndrome, mechanisms of drug resistance, drug-induced metabolic reporgraming, drug discovery
Research description
Research in the Ge laboratory focuses on the translational studies of acute myeloid leukemia (AML) in children and adults including myeloid leukemia associated with Down syndrome. We use cell lines, primary patient specimens, and cell line- and patient-derived xenograft models. Leukemia is the most common form of childhood cancer and cancer is the leading cause of death from disease of American children. Hence, improving leukemia therapy is of utmost importance in pediatric health. This is particularly relevant to AML in which progress has lagged significantly in comparison to childhood acute lymphoblastic leukemia. AML is even more challenging to treat in the elderly due to decreased tolerability to intensive therapy and increased therapy-related mortality. Resistance to cytarabine- and anthracycline-based chemotherapy is a major cause of treatment failure in this disease. Therefore, new therapies for patients with AML are urgently needed to overcome drug resistance, decrease relapse rates, and reduce short- and long-term adverse effects of treatment. The Ge laboratory studies are currently focusing on the antileukemic activity and molecular basis for novel targeted agents, including histone deacetylase (HDAC) inhibitors (HDACIs), Bcl-2 inhibitors, FLT3 inhibitors, cell cycle checkpoint inhibitors, and mitochondria-targeting agents, either alone or in combination, in preclinical models of AML. In collaboration with Drs. Gavande, Dou, and Polin, the Ge lab is discovering and developing small molecule inhibitors for USP5 and USP13 for the treatment of AML and other cancers.
PubMed - my bibliography
Education/training
PhD (1998): Jilin University, Changchun, China