Maik Huettemann, Ph.D.
Address
3214 Scott Hall 540 East Canfield Detroit, MI 48201Office address
3214 Scott Hall
540 East Canfield
Detroit, MI 48201
Department
Center for Molecular Medicine and Genetics, Department of Biochemistry, Microbiology and Immunology
Laboratory web site
http://www.genetics.wayne.edu/faculty/maik-huttemann
Keywords
Mitochondria, cancer metabolism (Warburg effect), apoptosis, cytochrome c, cytochrome c oxidase, cell signaling, near infrared light therapy
Research interests
• Effect of cell signaling on mitochondrial metabolism, cytochrome c, and cytochrome c oxidase.
• Mitochondrial metabolism in cancer.
• Development of mitochondria-targeted therapies for ischemia/reperfusion injury as seen in stroke and myocardial infarction.
Research description
Dr. Hüttemann's team studies mitochondrial function using genetic, biochemical, and functional approaches. The group focuses on two key components of the mitochondrial oxidative phosphorylation machinery, cytochrome c oxidase (COX) and the small electron carrier cytochrome c (Cytc). COX is the terminal enzyme of the mitochondrial respiratory chain, "burns" the oxygen we breathe to water, and pumps protons across the inner mitochondrial membrane generating the mitochondrial membrane potential, which is utilized by ATP synthase to produce energy in the form of ATP. Cytc has two distinct functions: it delivers electrons to COX, but it also participates in programmed cell death (apoptosis). Together the two proteins play a key role in life and death decisions of the cell via energy production under healthy conditions and free radical generation and apoptosis under conditions of cellular stress. The overall goal is to understand the regulation of COX and Cytc in normal and disease conditions including cancer, and to apply this knowledge for diagnosis and treatment.
PubMed - my bibliography
Education/training
BS in Chemistry (1992): Philipps-University Marburg, Germany
MS in Chemistry and Biochemistry (1995): Philipps-University Marburg, Germany
PhD in Biochemistry and Molecular Biology (1999): Philipps-University Marburg, Germany
Courses taught by Maik Huettemann, Ph.D.
Winter Term 2026 (future)
- MGG7030 - Functional Genomics and Systems Biology
- MGG8770 - Molecular Biology of Mitochondrial Disease
- IBS7030 - Functional Genomics and Systems Biology
Fall Term 2025 (current)
Winter Term 2025
- IBS7030 - Functional Genomics and Systems Biology
- MGG7030 - Functional Genomics and Systems Biology
- MGG8770 - Molecular Biology of Mitochondrial Disease
Fall Term 2024
Winter Term 2024
- MGG7030 - Functional Genomics and Systems Biology
- MGG8770 - Molecular Biology of Mitochondrial Disease
- IBS7030 - Functional Genomics and Systems Biology