Michael Joiner

Michael Joiner

 Professor

313-576-8344

joinerm@wayne.edu

Michael Joiner

Address

4100 John R. Detroit, MI 48201

Office Address

Gershenson Radiation Oncology Center

4100 John R 
Detroit, MI 48201-2013
 

Research Description

In research, I have specialized in biophysics and experimental radiation oncology using in vitro and in vivo models at both the basic and the translational level. I discovered low-dose hyper-radiosensitivity and the inverse very low dose-rate effect, both processes can be major factors influencing the extent and type of molecular signaling and DNA repair following irradiation and can therefore determine the overall survival of stem cells and tissue toxicity following X-ray exposure. I have spent most of my career investigating how clinical radiotherapy can be made more effective using both manipulations of the radiation delivery schedule and also by the addition of chemical modifiers of effect. I therefore have a considerable understanding of how to recognize and quantify radiation effects, the underlying radiobiology and molecular basis of those effects, as well as the medical physics and biophysics of radiation delivery and dosimetry. This broad interest and experience enables me to make a valued contribution to researching the use of more effective radiotherapy. It has also enabled me to develop an effective and valued role in educating and mentoring at undergraduate, graduate and post-graduate/professional level. I develop and sole-teach my own courses at Wayne State University, I joint-teach many other local courses, and I continue to teach at national and international courses. I am editor of the textbook “Basic Clinical Radiobiology” and author on 8 chapters. This book, the 5th edition published in September 2018, is used in training programs worldwide and also to assist in advanced education in radiation sciences.

Recent Publications

Shaikh MY, Burmeister J, Scott R, Kumaraswamy LK, Nalichowski A, Joiner MC. Dosimetric evaluation of incorporating the revised V4.0 calibration protocol for breast intraoperative radiotherapy with the INTRABEAM system. J Appl Clin Med Phys. 2020;21:50-59.

Shaikh MY, Joiner MC, Nalichowski A, Kumaraswamy LK, Burmeister J. Evaluation of the dosimetric impact of manufacturing variations for the INTRABEAM x-ray source. J Appl Clin Med Phys. 2020;21:20-31.

Howell K, Matuszak M, Maitz CA, Eisaman SH, Padilla L, Brown SL, Joiner MC, Dominello MM, Burmeister J. Three Discipline Collaborative Radiation Therapy (3DCRT) special debate: In the future, at least 20% of NIH funding for radiotherapy research should be allocated to non-oncologic applications. J Appl Clin Med Phys. 2020;21:7-13.

Grassberger C, Huber K, Jacob NK, Green MD, Mahler P, Prisciandaro J, Dominello M, Joiner MC, Burmeister J. Three discipline collaborative radiation therapy (3DCRT) special debate: The single most important factor in determining the future of SBRT is immune response. J Appl Clin Med Phys. 2019;20:6-12.

Kim L, Markovina S, Van Nest SJ, Eisaman S, Santanam L, Sullivan JM, Dominello M, Joiner MC, Burmeister J. Three discipline collaborative radiation therapy (3DCRT) special debate: Equipment development is stifling innovation in radiation oncology. J Appl Clin Med Phys. 2019;20:6-11.

Carrier F, Liao Y, Mendenhall N, Guerrieri P, Todor D, Ahmad A, Dominello M, Joiner MC, Burmeister J. Three Discipline Collaborative Radiation Therapy (3DCRT) Special Debate: I would treat prostate cancer with proton therapy. J Appl Clin Med Phys. 2019;20:7-14.

Soisson E, Guerrieri P, Balasubramanian S, Ahamad A, Moran JM, Joiner MC, Dominello M, Burmeister J. Three discipline collaborative radiation therapy special debate: All head and neck cancer patients with intact tumors/nodes should have scheduled adaptive replanning performed at least once during the course of radiotherapy. J Appl Clin Med Phys. 2019;20:7-11.

Mohindra P, Sawant A, Griffin RJ, Lamichhane N, Vlashi E, Xu-Welliver M, Dominello M, Joiner MC, Burmeister J. Three discipline collaborative radiation therapy (3DCRT) special debate: I would treat all early-stage NSCLC patients with SBRT. J Appl Clin Med Phys. 2019;20:7-13.

Braunstein S, Wang L, Newhauser W, Tenenholz T, Rong Y, van der Kogel A, Dominello M, Joiner MC, Burmeister J. Three discipline collaborative radiation therapy (3DCRT) special debate: The United States should build additional proton therapy facilities. J Appl Clin Med Phys. 2019;20:7-12.

Burmeister JW, Dominello MM, Tracey MW, Kacin SE, Joiner MC. In Reply to Malicki. Int J Radiat Oncol Biol Phys. 2018;102:1592-3.

Waselewski A, Joiner M, Miller SR. Acute myeloid leukaemia relapse presenting as cardiac myeloid sarcoma. BMJ Case Rep. 2018;bcr-2018-224419.

Burmeister JW, Tracey MW, Kacin SE, Dominello MM, Joiner MC. Improving Research in Radiation Oncology through Interdisciplinary Collaboration. Radiat Res. 2018;190:1-4.

Tracey MW, Joiner M, Kacin S, Burmeister J. A Collaborative Educational Intervention Integrating Biology and Physics in Radiation Oncology: A Design Research Case Study. Contemp Educ Technol. 2018;9:186-205.

Burmeister JW, Tracey MW, Kacin SE, Dominello MM, Joiner MC. …of Radiation Oncology, Biology, and Physics. Int J Radiat Oncol Biol Phys. 2018;100:1289-90.

Rodrigues-Moreira S, Moreno SG, Ghinatti G, Lewandowski D, Hoffschir F, Ferri F, Gallouet AS, Gay D, Motohashi H, Yamamoto M, Joiner MC, Gault N, Romeo PH. Low-dose irradiation promotes persistent oxidative stress and decreases self-renewal in hematopoietic stem cells. Cell Rep. 2017;20:3199-211.

Dominello MM, Fountain MD, Rothstein SE, Cannon AC, Abernathy LM, Hoogstra D, Chen W, Joiner MC, Hillman GG. Radiation injury to cardiac arteries and myocardium is reduced by soy isoflavones. J Radiat Oncol. 2017;6:307-15.

Joiner MC, Tracey MW, Kacin SE, Burmeister JW. IBPRO – a novel short-duration teaching course in advanced physics and biology underlying cancer radiotherapy. Radiat. Res. 2017;187:637-40.

Abernathy LM, Fountain MD, Joiner MC, Hillman GG. Innate immune pathways associated with lung radioprotection by soy isoflavones. Front Oncol. 2017;7:7.

Selected Publications

Seth I, Schwartz JL, Stewart RD, Emery R, Joiner MC, Tucker JD. Neutron exposures in human cells: bystander effect and relative biological effectiveness. PLoS One. 2014;9:e98947.

Bakhmutsky MV, Joiner MC, Jones TB, Tucker JD. Differences in cytogenetic sensitivity to ionizing radiation in newborns and adults. Radiat Res. 2014;181:605-16.

Tucker JD, Joiner MC, Thomas RA, Grever WE, Bakhmutsky MV, Chinkhota CN, Smolinski JM, Divine GW, Auner GW. Accurate gene expression-based biodosimetry using a minimal set of human gene transcripts. Int J Radiat Oncol Biol Phys. 2014;88:933-9.

Tucker JD, Divine GW, Grever WE, Thomas RA, Joiner MC, Smolinski JM, Auner GW. Gene expression-based dosimetry by dose and time in mice following acute radiation exposure. PLoS One. 2013;8(:e83390.

Tucker JD, Vadapalli M, Joiner MC, Ceppi M, Fenech M, Bonassi S. Estimating the lowest detectable dose of ionizing radiation by the cytokinesis-block micronucleus assay. Radiat Res. 2013;180:284-91.

Cheong HS, Seth I, Joiner MC, Tucker JD. Relationships among micronuclei, nucleoplasmic bridges and nuclear buds within individual cells in the cytokinesis-block micronucleus assay. Mutagenesis. 2013;28:433-40. 

Seth I, Joiner MC, Tucker JD. Cytogenetic low-dose hyper-radiosensitivity is observed in human peripheral blood lymphocytes. Int J Radiat Oncol Biol Phys. 2015;91:82-90.

Joshi GS, Joiner MC, Tucker JD. Cytogenetic characterization of low-dose hyper-radiosensitivity in Cobalt-60 irradiated human lymphoblastoid cells. Mutat Res. 2014;770:69-78.

Liao Y, Joiner MC, Huang Y, Burmeister J. Hypofractionation: what does it mean for prostate cancer treatment? Int J Radiat Oncol Biol Phys. 2010;76:260-8.

Joiner MC, Mogili N, Marples B, Burmeister J. Significant dose can be lost by extended delivery times in IMRT with x rays but not high-LET radiations. Med Phys. 2010;37:2457-65.

Marples B, Wouters BG, Joiner MC. An association between the radiation-induced arrest of G2 cells and low-dose hyper-radiosensitivity: A plausible underlying mechanism? Radiat Res. 2003;160:38-45.

Marples B, Joiner MC. The response of Chinese hamster V79 cells to low radiation doses: evidence of enhanced sensitivity of the whole cell population. Radiat Res. 1993;133:41-51.

Joiner MC, Johns H. Renal damage in the mouse: The response to very small doses per fraction. Radiat Res. 1988;114:385-98.

Joiner MC, Denekamp J, Maughan RL. The use of ‘top-up’ experiments to investigate the effect of very small doses per fraction in mouse skin. Int J Radiat Biol. 1986;49:565-80.

Joiner MC, Steel GG, Stephens TC. Response of two mouse tumours to hyperthermia with CCNU or melphalan. Br J Cancer. 1982;45:17-26.
 

Education/Training

Ph.D. (1980), University of London, England

Courses Taught

CB7210 Fundamentals of Cancer Biology
CB7220 Molecular Biology of Cancer Development
CB7300 Special Topics Basic Clinical Radiobiology (Course Director)
CB7240 Principles of Cancer Therapy 

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