Address

421 E Canfield Room 1248, Detroit MI 48201

Mentoring

 Jessica Long (PhD student)

Department

 Oncology

Laboratory Web Site

wilsonlabwayne.com

Research Interests

• Gynecologic oncology
• Obesity and diabetes in cancer
• Genetically engineered mouse models
 

Research Description

Our research laboratory studies uterine cancer. In this endeavor, we have several goals 1) to understand the relationship between obesity and uterine cancer and 2) to characterize the function of tumor suppressors which have not been described. Our lab utilizes genetically engineered mouse models, cancer cell lines and patient tissues to perform genetic, epigenetic and metabolic experiments related to these goals. Overall, we hope to discover new biomarkers for response to existing treatments, identify new therapeutic targets and understand the mechanisms driving racial disparities related to this disease.

 

Recent Publications

Wilson M.R., Harkins S., Reske J.J., Siwicki R.A., Adams M., Bae-Jump V.L., Teixeira J.M., Chandler R.L.. PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin. Reprod Biol Endocrinol. 21(1). 2023

Wilson M.R., Skalski H., Reske J.J., Wegener M., Adams M., Hostetter G., Hoffmann H.M., Bernard J.J., Bae‐Jump V.L., Teixeira J.M., Chandler R.L. Obesity alters the mouse endometrial transcriptome in a cell context-dependent manner. Reprod Biol Endocrinol. 20(1):163. 2022

Wilson, M.R, Reske J.J., Chandler R.L. AP-1 subunit JUNB promotes invasive phenotypes in endometriosis. Reprod Sci. 2022 May 26. doi: 10.1007/s43032-022-00974-3. Online ahead of print.

Wilson M.R., Reske J.J., Koeman J., Adams M., Joshi N.R., Fazleabas A.T., Chandler R.L. SWI/SNF Antagonism of PRC2 Mediates Estrogen-Induced Progesterone Receptor Expression. Cells. 2022;11:1000.

Wilson, M.R., Reske, J.J., Holladay, J., Neupane, S., Ngo, J., Cuthrell, N., Wegener, M., Rhodes, M., Adams, M., Sheridan, R., Hostetter, G., Alotaibi, F.T., Yong, P.J., Anglesio, M.S., Lessey, B.A., Leach, R.E., Teixeira, J.M., Missmer, S.A., Fazleabas, A.T., Chandler, R.L. ARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation. Cell Rep. 2020;10;33:108366.

Wilson, M.R, Holladay, J., Sheridan, R., Hostetter, G., Berghuis, B., Graveel, C., Essenburg, C., Peck, A., Ho, T.H., Stanton, M., Chandler, R.L. Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta. Stem Cell Res. 2020;46:101849.

Wilson, M.R, Holladay, J., Chandler, R.L. A mouse model of endometriosis mimicking the natural spread of invasive endometrium. Hum Reprod. 2020;35:58-69.

Wilson, M.R., Reske, J.J., Holladay, J., Wilber, G.E., Rhodes, M., Koeman, J., Adams, M., Johnson, B., Su, R.W., Joshi, N.R., Patterson, A.L., Shen, H., Leach, R.E., Teixeira, J.M., Fazleabas, A.T., Chandler, R.L. ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion. Nat Commun. 2019;10:3554.

Wilson M.R., Hou Z., Wilson L.J., Ye J., Matherly L.H. Determining the role of the transmembrane domain 6/7 linker of the proton-coupled folate transporter via folate transporter/thiamine transporter chimeras. Biochem J. 2016;15;473:3545-62.

Wilson M.R., Hou Z., Yang S., Polin L., Kushner J., White K., Huang J., Ratnam M., Gangjee A., Matherly L.H. Targeting non-squamous non-small cell lung cancer via the proton-coupled folate transporter with 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates. Mol Pharmacol. 2016;89:425-34.

Wilson M.R., Kugel S., Huang J., Wilson L.J., Wloszczynski P.A., Ye J., Matherly L.H., Hou Z. Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6. Biochem J. 2015;469:33-44.

Wilson, M.R., Hou, Z., & Matherly, L.H. Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter. J Biol Chem. 2014;289:25287-95.
 

Education/Training

B.S. 2011 Grand Valley State University
Ph.D. 2016 Wayne State University
Postdoc 2022 Michigan State University

 

Courses Taught

CB7890 Student Seminar
CB7300 F31/F30 Grant Writing Course

← Return to listing