Michael Wilson

Michael Wilson

Assistant Professor



Michael Wilson


421 E Canfield Room 1248, Detroit MI 48201



Laboratory Web Site


Research Interests

• Gynecologic oncology
• Obesity and diabetes in cancer
• Genetically engineered mouse models

Research Description

The research lab studies gynecologic oncology. A current focus of the lab is to elucidate the role of obesity in contributing to endometrial cancer. Our goal is to identify novel targets which can be used to develop therapies for endometrial cancer. Pathways of interest include PI3K, endoplasmic reticulum stress and interferon signaling.

Recent Publications

Wilson, M.R, Reske J.J., Chandler R.L. AP-1 subunit JUNB promotes invasive phenotypes in endometriosis. Reprod Sci. 2022 May 26. doi: 10.1007/s43032-022-00974-3. Online ahead of print.

Wilson M.R., Reske J.J., Koeman J., Adams M., Joshi N.R., Fazleabas A.T., Chandler R.L. SWI/SNF Antagonism of PRC2 Mediates Estrogen-Induced Progesterone Receptor Expression. Cells. 2022;11:1000.

Wilson, M.R., Reske, J.J., Holladay, J., Neupane, S., Ngo, J., Cuthrell, N., Wegener, M., Rhodes, M., Adams, M., Sheridan, R., Hostetter, G., Alotaibi, F.T., Yong, P.J., Anglesio, M.S., Lessey, B.A., Leach, R.E., Teixeira, J.M., Missmer, S.A., Fazleabas, A.T., Chandler, R.L. ARID1A mutations promote P300-dependent endometrial invasion through super-enhancer hyperacetylation. Cell Rep. 2020;10;33:108366.

Wilson, M.R, Holladay, J., Sheridan, R., Hostetter, G., Berghuis, B., Graveel, C., Essenburg, C., Peck, A., Ho, T.H., Stanton, M., Chandler, R.L. Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta. Stem Cell Res. 2020;46:101849.

Wilson, M.R, Holladay, J., Chandler, R.L. A mouse model of endometriosis mimicking the natural spread of invasive endometrium. Hum Reprod. 2020;35:58-69.

Wilson, M.R., Reske, J.J., Holladay, J., Wilber, G.E., Rhodes, M., Koeman, J., Adams, M., Johnson, B., Su, R.W., Joshi, N.R., Patterson, A.L., Shen, H., Leach, R.E., Teixeira, J.M., Fazleabas, A.T., Chandler, R.L. ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion. Nat Commun. 2019;10:3554.

Wilson M.R., Hou Z., Wilson L.J., Ye J., Matherly L.H. Determining the role of the transmembrane domain 6/7 linker of the proton-coupled folate transporter via folate transporter/thiamine transporter chimeras. Biochem J. 2016;15;473:3545-62.

Wilson M.R., Hou Z., Yang S., Polin L., Kushner J., White K., Huang J., Ratnam M., Gangjee A., Matherly L.H. Targeting non-squamous non-small cell lung cancer via the proton-coupled folate transporter with 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates. Mol Pharmacol. 2016;89:425-34.

Wilson M.R., Kugel S., Huang J., Wilson L.J., Wloszczynski P.A., Ye J., Matherly L.H., Hou Z. Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6. Biochem J. 2015;469:33-44.

Wilson, M.R., Hou, Z., & Matherly, L.H. Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter. J Biol Chem. 2014;289:25287-95.


B.S. 2011 Grand Valley State University
Ph.D. 2016 Wayne State University
Postdoc 2022 Michigan State University


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