Address

4100 John R, mail code: HW05AO Detroit, MI 48201

Department

 Oncology

Laboratory Web Site

 https://imaginglab.org/

Research Interests

• Strategies to combine nuclear medicine for imaging/therapy and track in-vivo responses using optoacoustics
• Synthesis of molecules/peptides as tumor-targeting agents
• Optoacoustic imaging to assess pathophysiological signatures of cancer

Research Description

My lab is evaluating new probes and strategies for combining radioligand and optoacoustic tools to study cancers. My main focus is to selectively label malignant growths in vivo to allow for their detection, treatment, and removal. Our goal is to be able to map out and observe imaging/therapeutic response via optoacoustics, which will ultimately benefit patients for early detection of cancer and non-invasive monitoring.

Recent Publications

C. Huang, N.R. Filippone, T. Reiner, S. Roberts*, Sensors and Inhibitors for the Detection of Ataxia Telangiectasia Mutated (ATM) Protein Kinase. Mol. Pharmaceutics 2021;18:2470-81.

S. Roberts, E. Khera, C. Choi, T. Navaratna, J. Grimm, GM. Thurber, and T. Reiner*. Optoacoustic imaging of GLP-1 Receptor with a near-infrared exendin-4 analog. J. Nucl. Med. 2021;62:10.

PMR. Pereira‡, S. Roberts‡, F. Figueira, JPC. Tome, T. Reiner, JS. Lewis*, PET/CT imaging with a 18 F- labeled galactodendritic unit in a galectin-1 overexpressing orthotopic bladder cancer model. J. Nucl. Med. 2020;61:1369-75.

HM. Schöder, PDS. França, R. Nakajima, EM Burnazi, S. Roberts, C. Brand, M. Grkovski, A. Mauguen, MPS Dunphy, R. Ghossein, SK Lyashchenko, JS Lewis, JA O'Donoghue, I. Ganly, SG. Patel, LY Nancy, T. Reiner*, Safety and feasibility of PARP1/2 imaging with 18F-PARPi in patients with head and neck cancer. Clinical Cancer Research 2020;26:3110-6.

K. Haedicke, L. Agemy, M. Omar, A. Berezhnoi, S. Roberts, C. Longo-Machado, M. Skubal, K. Nagar, H. Hsu, K. Kim, T. Reiner, J. Coleman, V. Ntziachristos, A. Scherz, J. Grimm*. High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies. Nature Biomedical Engineering 2020;4:286-97.

S. Roberts, A. Strom, C. Choi, C. Andreou, S. Kossatz, C. Brand, T. Williams, M. Bradbury, MF. Kircher, YK. Reshetnyak, J. Grimm, JS. Lewis, T. Reiner*, Acid specific dark quencher QC1 pHLIP for multi- spectral optoacoustic diagnoses of breast cancer. Scientific Reports 2019;9:8550.

G. Pirovano, S. Roberts, T. Reiner*, TOPKi-NBD: a fluorescent small molecule for tumor imaging. Eur J Nucl Med Mol Imaging 2019;47:1003-10.

S. Roberts, C. Andreou, C. Choi, P. DonabedianY, M. Jayaraman1, EC Pratt, J. Tang, C. Pérez-Medina, MJ. Cruz, WJM Mulder, J. Grimm, M. Kircher, T. Reiner*, Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer. Chem. Sci., 2018;9:5646-57.

S. Roberts, M. Seeger, Y. Jiang, A. Mishra, F. Sigmund, A. Stelzl, A. Lauri, P. Symvoulidis, H. Rolbieski, M. Preller, XL Deán-Ben, D. Razansky, T. Orschmann, SC Desbordes, P. Vetschera, T. Bach, V. Ntziachristos, G.G Westmeyer*. Calcium Sensor for Photoacoustic Imaging. J. Am. Chem. Soc. 2018;140:2718-21.

 

Education/Training

 M.Sc. 2011 University of St. Andrews, St. Andrews, Scotland
Ph.D. 2017 Technical University Munich (TUM), Munich, Germany
Postdoc 2022 Memorial Sloan Kettering Cancer Center (MSK), New York, USA

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