Howard Crawford

Howard Crawford

Senior Scientist


Howard Crawford


2799 West Grand Blvd Detroit, MI 48202

Office Address

 E&R 7018


Department of Surgery, Henry Ford Health
Department of Pharmacology, Wayne State University

Recent Publications

Kremer DM, Nelson BS, Lin L, Yarosz EL, Halbrook CJ, Kerk SA, Sajjakulnukit P, Myers A, Thurston G, Hou SW, Carpenter ES, Andren AC, Nwosu ZC, Cusmano N, Wisner S, Mbah NE, Shan M, Das NK, Magnuson B, Little AC, Savani MR, Ramos J, Gao T, Sastra SA, Palermo CF, Badgley MA, Zhang L, Asara JM, McBrayer SK, di Magliano MP, Crawford HC, Shah YM, Olive KP, Lyssiotis CA. GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Nat Commun. 2021;12:4860.

Kemp SB , Carpenter ES, Nwosa ZC, Steele NG , Donahue KL, Pacheco A, Velez-Delgado A, Menjivar RE, Lima F, The S, Espinoza C, Long D, Zhang Y, Lyssiotis CA , Rao A, Pasca di Magliano M, Crawford HC. Apolipoprotein E promotes immune suppression through NF-B mediated CXCL1 production in pancreatic cancer. Cancer Res, 2021;81:4305-18.

Steele NG, Carpenter ES, Kemp SB, Sirihorachai V… Lyssiotis CA, Zou W, Allen BL, Rao A, Crawford HC*, Bednar F*, Frankel TL*, Pasca di Magliano M*. Multimodal Mapping of the Immune Landscape in Human Pancreatic Cancer. Nature Cancer. 2020;1:1097-112 *co-corresponding authors

Hoffman MT, Kemp SK, Salas-Escabillas DJ, Zhang Y, Steele NG, The S, Rao A, Long D, Benitz S, Yan W, Margolskee RF, Bednar F, Pasca di Magliano M, Wen H-J and Crawford HC. The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice. Cell Mol Gastroenterol Hepatol. 2021;11:349-69.

Ruggeri JM, Franco-Barraza J, Sohail A, Zhang Y, Long D, Pasca di Magliano M, Cukierman E, Fridman, Crawford HC. Discoidin Domain Receptor 1 (DDR1) is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma. Am J Pathol. 2020;190:1735-51.

Wen H-J, Gao S , Wang Y, Ray M, Skelton J, Magnuson MA, Wright CVE, Pasca Di Magliano M, and Crawford HC. Macrophage-derived HB-EGF contributes to pancreatic tissue recovery from pancreatitis. Cell Mol Gastroenterol Hepatol. 2019;8:173-92.


 BA, 1987, Cornell University
PhD, 1993, University of Texas Southwestern Medical Center


← Return to listing