Moray Campbell
Address
Barbara Ann Karmanos Cancer Institute Wayne State University School of Medicine 4100 John R, Detroit, MI 48201Department
Oncology
Research interests
• Defining gene regulatory networks that sustain disease progression and therapy resistance in hormone-dependent cancers
• Understanding how the cancer epigenome shapes transcriptional responsiveness to intrinsic and extrinsic signals
• Applying integrative, scalable bioinformatic approaches to leverage high-dimensional genomic data
Research description
Rather than viewing transcriptional signals as fixed pathways, the Campbell lab studies these as dynamic, context-dependent regulatory networks shaped by the chromatin state, co-regulators, and post-transcriptional controls. Research focuses on how chromatin organization combines with transcription factor and coregulator interactions to regulate gene regulatory networks that control disease progression, treatment response, and health disparities in hormone-dependent cancers. To achieve these goals, we combine targeted wet-lab perturbations (e.g., CRISPR technologies) with high-dimensional genomic data and scalable bioinformatics to understand how transcriptional control is rewired in cancer. Students work at the interface of molecular biology, genomics, and computational biology to identify regulatory features that predict therapeutic responses and reveal new strategies to restore differentiation and hormone sensitivities in cancer.