Daniel Luedtke

Daniel Luedtke
(Graduated 09/25/2019)

Dissertation Mentor: Yubin Ge, PhD.

Research Focus:
The modulation of Bcl-2 proteins to enhance cancer treatment in the Acute Myeloid Leukemia model

Grants, Awards, Scholarships:
2017 - 2018 DeRoy Testamentary Fellowship
2016 C.P. Lee Graduate Student Research Day, Wayne State University, 2nd place poster presentation
2015 Cancer Biology Director's Award, Wayne State University School of Medicine
2015 Cancer Biology Summer Undergraduate Research Fellowship


Luedtke DA, Su Y, Ma J, Buck SA, Edwards H, Polin S, Kushner J, Dzinic SH, White K, Lin H, Taub JW, and Ge Y*. Inhibition of CDK9 by Voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia. Signal Transduct Target Ther. Accepted.

Knight T, Luedtke D, Edwards H, Taub JW, Ge Y. A delicate balance - The BCL-2 family and its role in apoptosis, oncogenesis, and cancer therapeutics. Biochem Pharmacol. 2019;162:250-61.

Daniel A. Luedtke, Yongwei Su, Shuang Liu, Holly Edwards, Yue Wang, Hai Lin, Jeffrey W. Taub, Yubin Ge. Inhibition of XPO1 enhances cell death induced by ABT-199 in acute myeloid leukaemia via Mcl-1. J Cell Mol Med. 2018;00:1‐13.

Yi Liao, Liping Xu, Siyu Ou, Holly Edwards, Daniel Luedtke, Yubin Ge, and Zhihui Qin. H2O2/Peroxynitrite-Activated Hydroxamic Acid HDAC Inhibitor Prodrugs Show Antileukemic Activities against AML Cells. ACS Med Chem Lett. 2018:13;9:635-40.

Daniel A Luedtke, Xiaojia Niu, Yihang Pan, Jianyun Zhao, Shuang Liu, Holly Edwards, Kang Chen, Hai Lin, Jeffrey W Taub & Yubin Ge. Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells.  Signal Transduct Target Ther. 2017 Apr 7;2:17012.

Ma J, Li X, Su Y, Zhao J, Luedtke DA, Epshteyn V, Edwards H, Wang G, Wang Z, Chu R, Taub JW, Lin H, Wang Y, Ge Y. Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cells. Sci Rep. 2017;7:41950.

University of Minnesota, 2012 ; BS Chemistry

Hometown: Cleveland, WI