Lloyd and Marilyn Smith Endowed Chair for Breast Cancer Research
Professor, Department of Oncology
Address4100 John R, Mail Code EL01TM Detroit, MI 48201
4100 John R, Mail Code EL01TM
Detroit, MI 48201
DepartmentBarbara Ann Karmanos Cancer Institute
Laboratory Web Site
- genetic events that govern the initiation and progression of cancer
- genetically engineered mouse models for breast and pancreatic cancer
- peptide hormone and inflammatory cytokine signaling
The Wagner lab is centered on the mechanisms regulating the normal development of the mammary gland and pancreas and to identify genetic pathways that control the development of breast and pancreatic cancer.
Numerous genes have been identified that are crucial for normal development and cancer. Their role is being studied in our research group through their deregulated expression in transgenic animals and through their deletion from the mouse genome by homologous recombination. Specifically, our laboratory has the expertise to overexpress genes in a temporally and spatially controlled manner using the Tet system and to delete genes in a tissue-specific and temporally controlled fashion using the Cre/loxP recombination system. Current projects include the analysis of cytokine signaling through the JAK/STAT and PI3K/AKT pathways as well as the role of c-Myc and oncogenic Kras in the initiation and maintenance of pancreatic ductal adenocarcinoma.
Sakamoto, K.; P.D. Rädler; B.L. Wehde; A.A. Triplett; H. Shrestha; R.-M. Ferraiuolo; F. Amari; V. Coppola; A. Klinakis; Argiris Efstratiadis and K.-U. Wagner. Efficient tissue-type specific expression of target genes in a tetracycline-controlled manner from the ubiquitously active Eef1a1 locus. Sci. Rep. 2020;10:e207.
Ferraiuolo, R.-M.; K.C. Manthey; M.J. Stanton; A.A. Triplett and K.-U. Wagner. The multifaceted roles of the Tumor Susceptibility Gene 101 (TSG101) in normal development and disease. Cancers 2020;12:e450.
Wehde, B.L.; P.D. Rädler; H. Shrestha; S.J. Johnson; A.A. Triplett and K.-U. Wagner. Janus kinase 1 plays a critical role in mammary cancer progression. Cell Rep. 2018;25:2192–207.
Rädler, P.D.; B.L. Wehde and K.-U. Wagner. Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells. Mol. Cell. Endocrinol. 2017;451:31-9.
Rajbhandari, N.; W.C. Lin; B.L. Wehde, A.A. Triplett and K.U. Wagner. Autocrine IGF1 signaling mediates pancreatic tumor cell dormancy in the absence of oncogenic drivers. Cell Rep. 2017;18:2243-55.
Sakamoto, K.; B.L. Wehde; K.H. Yoo; T. Kim; N. Rajbhandari; H.Y. Shin; A.A. Triplett; P.D. Rädler; F. Schuler; A. Villunger; K. Kang; L. Hennighausen and K.-U. Wagner. Janus kinase 1 is essential for inflammatory cytokine signaling and mammary gland remodeling. Mol. Cell. Biol. 2016;36:1673-90.
Witkiewicz, A.K.; E.A. McMillan; U. Balaji; G. Baek; W.-C. Lin; J. Mansour; M. Mollaee. K.-U. Wagner, P. Koduru; A. Yopp; M.A. Choti; C.J. Yeo; P. McCue; M.A. White and E.S. Knudsen. Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets. Nature Communications 2015;6:6744.
B.Sc. 1990 University of Leipzig, Leipzig, Germany
M.Sc. 1991 University of Leipzig, Leipzig, Germany
Ph.D. 1995 University of Halle-Wittenberg, Germany
Postdoc 1995-2000 National Institute of Health
CB7300 Special Topics in Cancer Biology - F30/31 Grant Writing
IBS7015 Interdisciplinary Molecular and Cellular Biology