Adrianne Wallace-Povirk

Adrianne Wallace-Povirk
3rd Year                                  

Dissertation Mentor: Larry Matherly, Ph.D.

Research Focus:

Grants, Awards, Scholarships:
2016-2017 Cancer Biology Director's Award Wayne State University School of Medicine
2016 Summer Undergraduate Research Fellowship
2016 Travel Grant Award for International Folate Receptor Society


Zhanjun Hou, Leda Gattoc, Carrie O'Connor, Si Yang, Adrianne Wallace-Povirk, Christina George, Steve Orr, Lisa Polin, Kathryn White, Juiwanna Kushner, Robert T. Morris, Aleem Gangjee, and Larry H. Matherly. Dual targeting of epithelial ovarian cancer via folate receptor α and the proton-coupled folate transporter with 6-substituted pyrrolo[2,3-d]pyrimidine antifolates. 2017 Jan 30. [Epub ahead of print]

Lalit K. Golani, Adrianne Wallace-Povirk, Siobhan M. Deis, Jennifer E. Wong, Jiyuan Ke, Xin Gu, Sudhir Raghavan, Mike R. Wilson, Xinxin Li, Lisa Polin, Parker W. de Waal, Kathryn White, Juiwanna Kushner, Carrie O'Connor, Zhanjun Hou, H. Eric Xu, Karsten Melcher, Charles E. Dann III, Larry H. Matherly, and Aleem Gangjee. Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions Via Cellular Uptake by Folate Receptor α and the Proton-coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. Med Chem. 2016;59:7856-76.

Wang, L., Wallace, A., Raghavan, S., Deis, S., Wilson, M.,  Yang, S., Polin, L., White, K.,  Kushner, J.,  Orr, S., George, C., O'Connor, C., Hou, Z.,  Mitchell-Ryan, S.,  Dann, C., Matherly, L.,  Gangjee., A. 6‐Substituted Pyrrolo[2,3‐d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors. Journal of Medicinal Chemistry. 2015;58):6938-59.

Mitton, K.P, Guzman, A., Deshpande M., Byrd, D., DeLooff, C., Mkoyan, K., Zlojutro, P., Wallace, A., Metcalf, B., Laux, K., Sotzen, J., Tran, T. Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice. Molecular Vision. 2014;20:1527-44.

Golani,L., George,C., Zhao, S., Raghavan, S., Orr,S, Wallace, A.,  Wilson, M., Hou, Z., Matherly, L., Gangjee, A. Structure−Activity Profiles of Novel 6‐Substituted Pyrrolo[2,3‐d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter. Journal of Medicinal Chemistry. 2014;57:8152-66.

Oakland University BS Biology, Honors College

Caro, MI