Katie Hege Hurrish
Senior Student 

Dissertation Mentor:  Yubin Ge, Ph.D.

Research focus: Targeting leukemia stem cells by pharmacologically interrupting mitochondrial respiration, potentially reducing the incidence of relapse in AML patients.

Grants, Awards, Scholarships:
2019 - 2020 T32-CA009531, Training Program in the Biology of Cancer, T32 Fellowship
2018 - 2019  Cancer Biology Director's Award
2018 - 2020 IBS Fellowship

Publications:

Li X, Su Y, Hege K, Madlambayan G, Edwards H, Knight T, Polin L, Kushner J, Dzinic SH, White K, Miller R, Wang G, Zhao L, Wang Y, Lin H, Taub JW, and Ge Y. The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia. Haematologica. 2021;106:1262-77.

Carter JL*, Hege K*, Yang J, Kalpage HA, Su Y, Edwards H, Hüttemann M, Taub JW, Ge Y. Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy. Signal Transduction and Targeted Therapy. 2020;5:288.

Carter JL, Hege K, Kalpage HA, Edwards H, Hüttemann M, Taub JW, Ge Y. Targeting mitochondrial respiration for the treatment of acute myeloid leukemia. Biochemical Pharmacology. 2020;182:114253

Li X, Su Y, Hege K, Madlambayan G, Edwards H, Knight T, Polin L, Kushner J, Dzinic SH, White K, Yang J, Miller R, Wang G, Zhao L, Wang Y, Lin H, Taub JW, Ge Y. The HDAC And PI3K Dual Inhibitor CUDC-907 Synergistically Enhances The Antileukemic Activity Of Venetoclax In Preclinical Models Of Acute Myeloid Leukemia. Haematologica.  2020 Mar 12. pii: haematol.2019.233445

Meyer K MD, Krueger SA PhD, Kane JL, Wilson TG, Hanna A MD, Dabjan M MD, Hege KM, Wilson GD PhD, Grills I MD, Marples B PhD. Pulsed Radiotherapy with Concurrent Cisplatin results in Superior Tumor Growth Delay in a Head and Neck Squamous Cell Carcinoma Murine Model. International Journal of Radiation Oncology Biology Physics. 2016;96:161-9.

Education:
M.S., Biological Sciences, Oakland University, 2016-2018
B.S., Biology, Grand Valley State University, 2008-2012

Hometown: Lake Orion, MI