Dissertation Mentor: Larry Matherly, Ph.D.
Research Focus: Targeting one-carbon metabolism in epithelial ovarian cancer via folate receptor alpha.
Grants, Awards, Scholarships:
Howard Hughes Medical Institute and the National Institute of Health Scholarship to attend the Jackson Laboratory 28th Annual Short Course on Experimental Models of Human Cancer
2019 -2021 National Institutes of Health "Targeting Mitochondrial One-Carbon Metabolism inEpithelial Ovarian Cancer" (F31CA243215; PI, A. Wallace-Povirk)
2019 Graduate Student Professional Travel Award to attend the Jackson Laboratory 28th Annual Short Course on Experimental Models of Human Cancer
2019 Graduate Student Professional Travel Award to attend American Association of Cancer Research AACR Annual Meeting
2018, 2019 Cancer Biology Student Scholar Award, American Association of Cancer Research Annual Meeting (Meeting Attendance Travel Award)
2018 - 2019 T32-CA009531, Training Program in the Biology of Cancer, T32 Fellowship
2017 - 2018 IBS Fellowship
2016 Travel Grant Award for International Folate Receptor Society
2016 - 2017 IBS Fellowship
2016 Cancer Biology Director's Award Wayne State University School of Medicine
2016 Summer Undergraduate Research Fellowship
Adrianne Wallace-Povirk, Nian Tong, Jennifer Wong-Roushar, Carrie O'Connor, Xilin Zhou, Zhanjun Hou, Xun Bao, Gloria E. Garcia, Jing Li, Seongho Kim, Charles E. Dann III, Larry H. Matherly, Aleem Gangjee. Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors. Bioorganic and Medicinal Chemistry. Provisionally accepted.
Aamod S. Dekhne, Chengwen Ning, Md. Junayed Nayeen, Khushbu Shah, Hasini Kalpage, Josphephine Fruhauf, Adrianne Wallace-Povirk, Carrie O'Connor, Zhanjun Hou, Seongho Kim, Maik Huttemann, Aleem Gangjee and Larry H. Matherly. Cellular pharmacodynamics of a novel pyrrolo[3,2-d]pyrimidine inhibitor targeting mitochondrial and cytosolic one-carbon metabolism. Molecular Pharmacology. 2020;97:9-22.
Aamod S. Dekhne, Khushbu Shah, Gregory S. Ducker, Jade M. Katinas, Jennifer Wong, Md. Junayed Nayeen, Arpit Doshi, Changwen Ning, Xun Bao, Josephine Frühauf, Jenney Liu, Adrianne Wallace-Povirk, Carrie O'Connor, Sijana H Dzinic, Kathryn White, Juiwanna Kushner, Seongho Kim, Maik Hüttemann, Lisa Polin, Joshua D. Rabinowitz, Jing Li, Zhanjun Hou, Charles E. Dann, Aleem Gangjee, and Larry H Matherly. Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy. Molecular Cancer Therapeutics. 2019;18:1787-99.
Ravindra M, Wallace-Povirk A, Karim MA, Wilson MR, O'Connor C, White K, Kushner J, Polin L, George C, Hou Z, Matherly LH, Gangjee A. Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. Journal of Medicinal Chemistry. 201;61:2027-40.
Zhanjun Hou, Leda Gattoc, Carrie O'Connor, Si Yang, Adrianne Wallace-Povirk, Christina George, Steve Orr, Lisa Polin, Kathryn White, Juiwanna Kushner, Robert T. Morris, Aleem Gangjee, and Larry H. Matherly. Dual targeting of epithelial ovarian cancer via folate receptor α and the proton-coupled folate transporter with 6-substituted pyrrolo[2,3-d]pyrimidine antifolates. Mol Cancer Ther. 2017;16:819-30.
Lalit K. Golani, Adrianne Wallace-Povirk, Siobhan M. Deis, Jennifer E. Wong, Jiyuan Ke, Xin Gu, Sudhir Raghavan, Mike R. Wilson, Xinxin Li, Lisa Polin, Parker W. de Waal, Kathryn White, Juiwanna Kushner, Carrie O'Connor, Zhanjun Hou, H. Eric Xu, Karsten Melcher, Charles E. Dann III, Larry H. Matherly, and Aleem Gangjee. Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions Via Cellular Uptake by Folate Receptor α and the Proton-coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. Med Chem. 2016;59:7856-76.
Wang, L., Wallace, A., Raghavan, S., Deis, S., Wilson, M., Yang, S., Polin, L., White, K., Kushner, J., Orr, S., George, C., O'Connor, C., Hou, Z., Mitchell-Ryan, S., Dann, C., Matherly, L., Gangjee., A. 6‐Substituted Pyrrolo[2,3‐d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors. Journal of Medicinal Chemistry. 2015;58:6938-59.
Mitton, K.P, Guzman, A., Deshpande M., Byrd, D., DeLooff, C., Mkoyan, K., Zlojutro, P., Wallace, A., Metcalf, B., Laux, K., Sotzen, J., Tran, T. Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice. Molecular Vision. 2014;20:1527-44.
Golani,L., George,C., Zhao, S., Raghavan, S., Orr,S, Wallace, A., Wilson, M., Hou, Z., Matherly, L., Gangjee, A. Structure−Activity Profiles of Novel 6‐Substituted Pyrrolo[2,3‐d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter. Journal of Medicinal Chemistry. 2014;57:8152-66.
Oakland University BS Biology, Honors College
Hometown: Caro, MI